Biomedical Engineering and Bioengineering Commons^™

3d Differentiation Enhances The Efficiency Of Differentiation Of Human Induced Pluripotent Stem Cells To Insulin Producing Cells, Pavana Gururaj Rotti

Theses and Dissertations

Type 1 Diabetes (T1D) is an autoimmune disorder in which the pancreatic β-cells are destroyed by the body's immune system. The reduced number of β-cells leads to inadequate insulin secretion and high glucose levels in the body. The requirement of insulin injection throughout life and lack of donors for islet transplantations has prompted a search for more accessible and available sources of insulin producing cells that can be transplanted in T1D patients. To that end, the discovery of induced pluripotent stem (iPS) cells has provided a potential source of precursors for cell therapy for T1D. iPS cells are reprogrammed ...