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Articles 1 - 15 of 15

Full-Text Articles in Biomedical Engineering and Bioengineering

Adaptation And Validation Of An Analytical Localized Muscle Fatigue Model For Workplace Tasks, John Maurice Looft Dec 2014

Adaptation And Validation Of An Analytical Localized Muscle Fatigue Model For Workplace Tasks, John Maurice Looft

Theses and Dissertations

Muscle fatigue is universally experienced in daily life, from recreational physical activity to the workplace. However, our ability to estimate fatigue is limited. Several attempts have been made to mathematically model the effects of fatigue, such as how long a muscle contraction may be sustained, known as `endurance time.' However, these simple models of endurance time are limited to static contractions when the body is not moving, but muscles are contracted. This research aims to advance a previously proposed analytical model of muscle fatigue to represent complex tasks such as with rest intervals and dynamic contractions. Multiple methodologies were employed ...


3d Differentiation Enhances The Efficiency Of Differentiation Of Human Induced Pluripotent Stem Cells To Insulin Producing Cells, Pavana Gururaj Rotti Dec 2014

3d Differentiation Enhances The Efficiency Of Differentiation Of Human Induced Pluripotent Stem Cells To Insulin Producing Cells, Pavana Gururaj Rotti

Theses and Dissertations

Type 1 Diabetes (T1D) is an autoimmune disorder in which the pancreatic β-cells are destroyed by the body's immune system. The reduced number of β-cells leads to inadequate insulin secretion and high glucose levels in the body. The requirement of insulin injection throughout life and lack of donors for islet transplantations has prompted a search for more accessible and available sources of insulin producing cells that can be transplanted in T1D patients. To that end, the discovery of induced pluripotent stem (iPS) cells has provided a potential source of precursors for cell therapy for T1D. iPS cells are reprogrammed ...


Early Targeting Of Knee Osteoarthritis : Validation Of Computational Methods, Tyler Joseph Stockman Aug 2014

Early Targeting Of Knee Osteoarthritis : Validation Of Computational Methods, Tyler Joseph Stockman

Theses and Dissertations

Osteoarthritis (OA) is the most common type of arthritis, a disease in which inflammation and stiffness of the joints occur. This debilitating disease of the joints currently reigns as the most prevalent among the world's populations. Of particular interest to our group is the study of the biomechanical factors relating to knee OA. Studies have shown that knee OA is related to multiple biomechanical factors, all of which are complexly interrelated. These factors have been seen to produce varied effects on the structures of the knee. This work examines validation of a computational model implementing discrete element analysis, and ...


The Effect Of Arch Insoles On Tibial Rotation And Tibiofemoral Contact Stress, Saphia Fatima Waheed Aug 2014

The Effect Of Arch Insoles On Tibial Rotation And Tibiofemoral Contact Stress, Saphia Fatima Waheed

Theses and Dissertations

No abstract provided.


Examining The Feasibility Of Magnetic Source Mri By Studying Fmri Acquisition And Analysis Strategies, Leo Ai Jul 2014

Examining The Feasibility Of Magnetic Source Mri By Studying Fmri Acquisition And Analysis Strategies, Leo Ai

Theses and Dissertations

Magnetic source magnetic resonance imaging (msMRI) is an fMRI technique that has been under development for direct detection of neuronal magnetic fields to map brain activity and has been shown to be experimentally detectable using conventional means, but there is debate on the detection of the msMRI signal since it can be only a 0.2% change. Detection of its temporal characteristics has yet to be reported and may strengthen the case for msMRI detection. The temporal characteristics of the detected msMRI signal were examined in this work, but it was found that the sensitivity of conventional analysis techniques are ...


Design And Application Of Methods For Curating Genetic Variation Databases, Sean Stephen Ephraim Jul 2014

Design And Application Of Methods For Curating Genetic Variation Databases, Sean Stephen Ephraim

Theses and Dissertations

Cordova (Curated Online Reference Database Of Variation Annotations) is an out-of-the-box solution for building and maintaining an online database of genetic variations integrated with population study information and pathogenicity prediction results from popular algorithms. Our primary motivation for developing this system is to aid researchers and clinician-scientists in determining the clinical significance of genetic variations. To achieve this goal, Cordova provides an interface to review and manually or computationally curate genetic variation data as well as share it for clinical diagnostics and the advancement of research.


Development Of A Surgical Simulation Toolkit For Mitral Valve Repair Surgeries, Piyusha Sanjay Gade Jul 2014

Development Of A Surgical Simulation Toolkit For Mitral Valve Repair Surgeries, Piyusha Sanjay Gade

Theses and Dissertations

Heart valve disease is estimated to cost over a billion dollars in the Unites States annually and mitral valve disorders account for the largest portion of the disease with treatments involving valve repair and replacement (Iung et. al). It is estimated that an experienced surgeon can effectively repair 95 - 100 percent of mitral valve (MV) disorders but a recent study showed that the average rate of MV repair is 41 percent. The current paradigm in treatments include diagnostic imaging data to see the current state of the patient, empirical data from previous similar cases to evaluate the efficacy of prior ...


Development Of Image Processing Tools And Procedures For Analyzing Multi-Site Longitudinal Diffusion-Weighted Imaging Studies, Joy Tamiko Matsui May 2014

Development Of Image Processing Tools And Procedures For Analyzing Multi-Site Longitudinal Diffusion-Weighted Imaging Studies, Joy Tamiko Matsui

Theses and Dissertations

The logistical complexities of performing multi-site longitudinal diffusion-weighted imaging (DWI) studies requires careful construction of analysis tools and procedures. Proposed clinical trials for therapies in neurodegenerative disease are known to re- quire several hundred subjects, thus mandating multiple site participation to obtain sufficient sample sizes. DWI is an important tool for monitoring diffusivity properties of white matter (WM) in disease progression. The multi-site nature of clinical trials requires new strategies in DWI processing and analysis to reliably measure longitudi- nal WM changes. This work describes the process of developing and validating robust analysis methodologies to process multi-site DWI data in ...


Preterm Birth: Prediction, Prevention, Care, Brandon Wesley Alleman May 2014

Preterm Birth: Prediction, Prevention, Care, Brandon Wesley Alleman

Theses and Dissertations

Preterm birth (PTB) is defined as birth before 37 weeks gestational age. PTB is a common outcome and one that may be increasing in prevalence with serious individual and public health implications both immediately and long term. While PTB is a pregnancy specific outcome it is more appropriately viewed as the culmination of risk factors present both before pregnancy and possibly in past generations. This thesis attempts to review the implications, risk factors and current prevention strategies directed at PTB while placing it in an intergenerational and life cycle context. Three novel investigations are presented and their consequences are discussed ...


Development Of A Nurbs-Based Particulate Dynamics Framework For Modeling Circulating Cells, Venkat Keshav Chivukula May 2014

Development Of A Nurbs-Based Particulate Dynamics Framework For Modeling Circulating Cells, Venkat Keshav Chivukula

Theses and Dissertations

The objective of this work is to develop a novel 3-D biological particulate dynamics framework to simulate blood flow in the micro circulation. This entails the amalgamation of concepts from various fields namely blood flow dynamics, solid mechanics, fluid-structure interaction and computational data structures. It is envisioned that this project will serve as a harbinger for implementing a multi-scale simulation model with applications in a vast array of situations from blood flows in heart valves to studying cancer metastasis. The primary motivation for this work stems from the need for establishing a simple, effective and holistic framework for performing blood ...


Computational And Experimental Biomechanics Of Total Hip Wear Increase Due To Femoral Head Damage, Karen Marie Kruger May 2014

Computational And Experimental Biomechanics Of Total Hip Wear Increase Due To Femoral Head Damage, Karen Marie Kruger

Theses and Dissertations

Aseptic loosening due to wear-induced osteolysis remains a leading cause of failure in total hip arthroplasty (THA), particularly in revision cases beyond the second decade of use. Historically, there have been large amounts of variability of wear within individual THA patient cohorts. Evidence indicates that femoral head damage can be a cause of this variability. While femoral head damage as a result of third body particles and subluxation and dislocation events has been well documented, direct quantifiable linkage between femoral head damage and wear acceleration remains to be established. Due to large ranges of observed retrieval damage, wear testing protocols ...


Interaction Of Blood Cells With The Vessel Wall In Thrombosis, Jessica Kay Hansen May 2014

Interaction Of Blood Cells With The Vessel Wall In Thrombosis, Jessica Kay Hansen

Theses and Dissertations

Thrombotic events such as stroke, myocardial infarction, or deep vein thrombosis can be life-threatening; therefore it is important to understand the mechanisms of thrombosis and its correlations with clinical risk factors. It is well known that red blood cells (RBCs) can influence hemostasis and thrombosis by affecting the viscosity and rheological properties of blood. Recent evidence suggests that RBCs may play a more central and active role in some models of experimental thrombosis by interacting directly with the endothelium. It is still unclear, however, if the interaction of RBCs with the endothelial surface is facilitated by other blood components. In ...


Understanding Mechanical Trade-Offs In Changing Centers Of Rotation For Reverse Shoulder Arthroplasty Design, Vijay Niels Permeswaran May 2014

Understanding Mechanical Trade-Offs In Changing Centers Of Rotation For Reverse Shoulder Arthroplasty Design, Vijay Niels Permeswaran

Theses and Dissertations

Though the literature contains many computational models studying RSA, very few utilize finite element analysis to study stresses in the implant and the surrounding bone. The introductions section shows that many parameters (center of rotation lateralization, center of rotation superior or inferior position, tilt of the cut glenoid surface, glenosphere shape design, glenosphere size, humeral design, notch severity, etc.) have been studied independently utilizing many different methods (finite element modeling and non-FE computational modeling). However, the introduction section also detailed the current limitations in modern modeling as well as many examples of the heights to which finite element modeling can ...


Investigation Of The Correlation Between Cerebral Blood Flow And Bold, Huijing Yang May 2014

Investigation Of The Correlation Between Cerebral Blood Flow And Bold, Huijing Yang

Theses and Dissertations

There are lots of dynamic process exist co-currently and spontaneously when the neurons in the brain are activated by the external stimulation, like cerebral blood flow (CBF) change, oxygen extraction change. The study of the dynamic relationship among these physiological variables, which describe the brain activity through different aspects, can help people understand the brain function when it gets excited and researchers can interpret the physiological meaning of these parameters better. The most common functional magnetic resonance imaging techniques are BOLD and ASL fMRI, in this research, the correlation between these two methods has been studied through a simultaneous data ...


Outcome Prediction In Head And Neck Cancer Patients Using Machine Learning Methods, David John Dellsperger May 2014

Outcome Prediction In Head And Neck Cancer Patients Using Machine Learning Methods, David John Dellsperger

Theses and Dissertations

Head and Neck cancers account for approximately 3.2% of the estimated 1,660,290 new cancer cases for the year 2013 and roughly 1.9% of cancer-related deaths in 2013. In this research, machine learning techniques were employed to predict outcome in cancer patients supporting more objective assessment of the treatments, including surgery, radiation therapy, or chemotherapy. Selection of features capable of distinguishing between the possible outcomes was accomplished by using a highly selective cohort of 61 patients with similar treatment and location of the primary tumor. An accuracy of 80.33% (compared to a baseline majority classifier of ...