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Full-Text Articles in Biomedical Engineering and Bioengineering

Fem Of Electrospinning Compared To Inkjet Printing Model, Maikel Ghaly Dec 2014

Fem Of Electrospinning Compared To Inkjet Printing Model, Maikel Ghaly

Theses

Electrospinning is a process that uses electrostatic forces to produce nanofibers, or fibers in the nano scale. Nanofibers are widely used in many fields like drug delivery and tissue engineering. Nowadays, it is gaining much attention in the research community as an advantageous process. However, there are many parameters that controlnanofiber formation. This research intends to develop a model of electrospinning on the basis of an inkjet printer technique by using a computer aided simulation (COMSOL). Inkjet printing is a technique that delivers small volumes at high repetitions which can betransported by electrostatic forces through the air onto their intended ...


An Electrospinning Apparatus For The Production Of Heterogeneous Scaffolds And Their Application In Cartilage Regeneration, Andrew Ryan Hollingsworth Dec 2014

An Electrospinning Apparatus For The Production Of Heterogeneous Scaffolds And Their Application In Cartilage Regeneration, Andrew Ryan Hollingsworth

Theses

The human body contains a vast array of soft and hard tissues, each with their own unique set of physical, chemical, mechanical, and electrical properties. It is the combination of these tissues that allows the human body to function as it does. However, these tissues are subject to wear, fatigue, and injury and thus can potentially limit the functions of the body. Therefore, tissue engineering has sought various natural and synthetic materials that can be used for fabrication of cellular scaffolds that have the ability to promote cellular attachment, proliferation, differentiation, and eventual whole tissue formation for replacement and repair ...


Visualeyes 2020: A Software Suite To Integrate Instrumentation To Study The Near Triad Of Vergence, Stephen J. Lestrange Dec 2014

Visualeyes 2020: A Software Suite To Integrate Instrumentation To Study The Near Triad Of Vergence, Stephen J. Lestrange

Theses

A complete instrumentation suite has been constructed for use in a randomized clinical trial to be funded from the National Institute of Health and study the underlying potential mechanism(s) of vision therapy. This suite is designed to track rotation of each eye (vergence) as well as measure the lens power of the eye's lens (accommodation). The system is designed to dissect the near triad which is composed of the pupil constriction, vergence and accommodation. The visual targets are programmed to be shown on two sets of computer screens which allowed vergence, accommodation and proximal vergence cues to be ...


Monitoring Of Cerebellar Injury Using Micro Ecog Signals In Ketamine/Xylazine Treated Rats, Gokhan Ordek Dec 2014

Monitoring Of Cerebellar Injury Using Micro Ecog Signals In Ketamine/Xylazine Treated Rats, Gokhan Ordek

Dissertations

Much of the cerebellar research has been conducted in anesthetized animals, particularly using ketamine/xylazine combination in rats, and yet the absolute impact of the anesthesia on the neural circuit remains unanswered . In the current study, spontaneous electrical activity and sensory evoked potentials from the cerebellar surface with chronically implanted, flexible-substrate, multielectrode arrays in rats were collected and analyzed with the motor cortex signals. The power spectra and the intercontact coherence plots of the spontaneous activity in the awake-quiet animals extended up to 800 Hz in the cerebellum and only up to 200 Hz in the motor cortex. Ketamine/xylazine ...


The Effect Of Vergence Vision Training On Binocularly Normal Subjects, Henry Talasan May 2014

The Effect Of Vergence Vision Training On Binocularly Normal Subjects, Henry Talasan

Theses

Vergence is the disjunctive (inward or outward) movement of the eyes that is stimulated by retinal disparity (difference of where an image is projected to the retina and the fovea). A recent randomized clinical trial showed the efficacy of vision therapy for children with the binocular dysfunction known as convergence insufficiency is 73%. However, it is unknown whether binocularly normal persons will have any significant change to their vergence ocular motor system if they participate in vision training sessions. A total of ten (n = 10) binocularly normal persons participated in this study (18 to 28 years of age). A haploscope ...


Short Term Modification Of Vergence Ramp Eye Movements In The Convergent Direction, Chang Yaramothu May 2014

Short Term Modification Of Vergence Ramp Eye Movements In The Convergent Direction, Chang Yaramothu

Theses

Prior oculomotor studies have investigated the various effects of short-term modification on vergence, saccadic and smooth pursuit eye movements. Previous vergence studies have concentrated on step modification stimuli. Few have investigated the effects of short-term modification on vergence ramp movements. Thus, this study explores the trends observed within a short-term modification experiment studying smoothly tracking vergence eye movements responses elicited from convergent ramp stimuli. A short-term modification experiment is composed of three phases: baseline, modification and recovery. Baseline and recovery phases contain only test stimuli; whereas, during modification, the subject is presented test and conditioning stimuli in a ratio of ...


Optimizing Alginate-Chitosan Microcapsules Using Co-Axial Air Flow Method As 3d Stem Cell Microenvironment, Noel Alfonso May 2014

Optimizing Alginate-Chitosan Microcapsules Using Co-Axial Air Flow Method As 3d Stem Cell Microenvironment, Noel Alfonso

Theses

Microencapsulation of cells is gaining popular interest in the field of biomedical engineering because it provides a more effective 3D scaffold that can mimic the cell microenvironment. The benefits of using microcapsules are biocompatibility, biodegradability, nontoxicity, and formation under mild gelation conditions. In this study, the ability of the alginate microcapsules to control the proliferation and differentiation of mouse OCT4-GFP embryonic stem cells is investigated. Microcapsules are produced by extrusion of alginate into a calcium chloride gelation bath with the aid of a co-axial air flow. It is shown that the size of the spheres is controlled based on needle ...


Evaluation Of Methods To Account For Release From Nanofiber Scaffolds, Jennifer Moy May 2014

Evaluation Of Methods To Account For Release From Nanofiber Scaffolds, Jennifer Moy

Theses

Electrospinning is a common technique utilized to form fibers from the micro- to nanometer range. Nanofibers form through electrospinning can be utilized as scaffolds since the fiber structures are similar to the structures within the extracellular matrix. Researchers use additives, such as growth factors, to help facilitate cell proliferation and function. Also, researchers are attempting to use electrospun fibers for drug delivery and as wound dressings since the electrospun fibers have high surface area to volume ratio. In both situations, the release of either the additive or the drug needs to be controlled so that the fibers would release the ...


Characterizing Motor Control Signals In The Spinal Cord, Yi Guo May 2014

Characterizing Motor Control Signals In The Spinal Cord, Yi Guo

Dissertations

The main goal of this project is to develop a rodent model to study the central command signals generated in the brain and spinal cord for the control of motor function in the forearms. The nature of the central command signal has been debated for many decades with only limited progress. This thesis presents a project that investigated this problem using novel techniques. Rats are instrumented to record the control signals in their spinal cord while they are performing lever press task they are trained in. A haptic interface and wireless neural data amplifier system simultaneously collects dynamic and neural ...