Biomedical Engineering and Bioengineering Commons^™

The Effect Of Biomechanical And Biochemical Factors On Endothelial Cells: Relevance To Atherosclerosis, Qiuquan Guo

Electronic Thesis and Dissertation Repository

Microscale technologies create great opportunities for biologists to unveil cellular or molecular mechanisms of complex biological processes. Advanced measuring techniques, like atomic force microscope (AFM), allow detecting and controlling biological samples at high spatial and temporal resolution. Further integration with microsystems, such as microfluidic platforms, gives the ability to get detailed insight into basic biological phenomena. Highly integrated microdevices show great promise for biomedical research and potential clinical applications.

It is hypothesized that biomechanical factors play a significant role in the development of vascular diseases like atherosclerosis. To explore effects of biomechanical and biochemical stimuli on endothelial cells (ECs), AFM, …

Modeling Lung Tissue Motions And Deformations: Applications In Tumor Ablative Procedures, Ali Sadeghi Naini

Electronic Thesis and Dissertation Repository

Various types of motion and deformation that the lung undergoes during minimally invasive tumor ablative procedures have been investigated and modeled in this dissertation. The lung frequently undergoes continuous large respiratory deformation, which can greatly affect the pre-planned outcome of the operation, hence deformation compensation becomes necessary. The first type of major deformation involved in a target lung throughout a tumor ablative procedure is the one encountered in procedures where the lung is totally deflated before starting the operation. A consequence of this deflation is that pre-operative images (acquired while the lung was partially inflated) become inaccurate for targeting the …

Development Of An Active Elbow Motion Simulator And Coordinate Systems To Evaluate Kinematics In Multiple Positions, Louis M. Ferreira

Electronic Thesis and Dissertation Repository

Elbow disorders are common as a consequence of both traumatic and degenerative conditions. Relative to disorders of the lower limb, there is comparatively little evidence to direct the treatment of many elbow disorders. Biomechanical studies are required to develop and validate the optimal treatment of elbow disorders prior to their application in patients. Clinically relevant simulation of elbow motion in the laboratory can be a powerful tool to advance our knowledge of elbow disorders. This work was undertaken with the rationale that simulation and quantification of elbow motion could be improved significantly. This treatise includes the development and evaluation of …