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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 7 of 7
Full-Text Articles in Biomedical Engineering and Bioengineering
Quantification Of 99mTc-Duramycin Uptake Kinetics In The Area-At-Risk After Myocardial Ischemia And Reperfusion, Joseph Capacete
Quantification Of 99mTc-Duramycin Uptake Kinetics In The Area-At-Risk After Myocardial Ischemia And Reperfusion, Joseph Capacete
Master's Theses (2009 -)
Myocardial infarction (MI) is a condition in which blood supply to the heart is insufficient. MI is associated with two forms of cell death: apoptosis and necrosis. 99mTc-duramycin (99mTc-D) is a novel radiopharmaceutical that detects cell death by recognizing externalized phosphatidylethanolamine. The objective of this study was to develop a compartmental model for 99mTc-D uptake kinetics in normal and infarct myocardium, and utilize this model to compare the uptake kinetics of 99mTc-D in MI with that of another radiopharmaceutical, 99mTc-C2A-GST.
MI was induced in rats which were then injected (i.v.) with 99mTc-D. Rats …
Design And Validation Of An Mr Conditional Upper Extremity Evaluation System To Study Brain Activation Patterns After Stroke, Rubing Xu
Master's Theses (2009 -)
Stroke is the third leading cause of death and second most frequent cause of disability in the United States. Stroke rehabilitation methods have been developed to induce the cortical reorganization and motor-relearning that leads to stroke recovery. In this thesis, we designed and developed an MR conditional upper extremity reach and grasp movement evaluation system for the stroke survivors to study their kinematic performances in reach and grasp movement and the relationship between kinematic metrics and the recovery level measured by clinical assessment methods. We also applied the system into the functional MRI experiments to identify the ability to study …
Image-Based Quantification Workflow For Coronary Morphology: A Tool For Use In Next-Generation Bifurcation Stent Design, Sara Marie Nomeland
Image-Based Quantification Workflow For Coronary Morphology: A Tool For Use In Next-Generation Bifurcation Stent Design, Sara Marie Nomeland
Master's Theses (2009 -)
Coronary artery disease (CAD) occurs in ~200,000 bifurcation lesions annually. Treatment of CAD near bends and bifurcations is challenging and a preferred strategy for bifurcation lesions has yet to be established. However, a favorable treatment option may be elucidated by a more thorough understanding of vessel morphology as well as local hemodynamic alterations caused by current stenting approaches. Computational modeling of human arteries offers an attractive way to investigate the relationships between geometry, hemodynamics and vascular disease. Recent developments also make it possible to perform analysis on realistic geometries acquired noninvasively.
The objective of this work was twofold. The first …
A Non-Rigid Registration Method For Analyzing Myocardial Wall Motion For Cardiac Ct Images, Elizabeth B. Philps
A Non-Rigid Registration Method For Analyzing Myocardial Wall Motion For Cardiac Ct Images, Elizabeth B. Philps
Master's Theses (2009 -)
Cardiac resynchronization therapy (CRT) has a high percentage of non-responders. Successfully locating the optimal location for CRT lead placement on a priori images can increase efficiency in procedural preparation and execution and could potentially increase the rate of CRT responders.
Registration has been used in the past to assess the motion of medical images. Specifically, one method of non-rigid registration has been utilized to assess the motion of left ventricular MR cardiac images. As CT imaging is often performed as part of resynchronization treatment planning and is a fast and accessible means of imaging, extending this registration method to assessing …
Sensitivity Of Motor Adaptation To The Statistical Properties Of An Environmental Load, Timothy Michael Haswell
Sensitivity Of Motor Adaptation To The Statistical Properties Of An Environmental Load, Timothy Michael Haswell
Master's Theses (2009 -)
Linear, limited-memory models capture many important features of adaptive motor performance during reaching, stepping and pointing. A recent study in our lab found that a model fitted to data obtained from subjects reaching against elastic loads which varied from trial-to-trial later failed to fit the steady-state response behavior of subjects exposed to deterministic, step changes in load. Does motor adaptation depend on statistical properties of the environment (eg. mean load strength and variability)? Neurologically intact volunteers (n=14) made 6 blocks of 100 planar, ballistic, 10cm, out-and-back reaching movements against spring-like loads having equilibrium positions at the hand's starting point. View …
Bi-Planar Postural Stability Model: Fitting Parameters To Patient Data Automatically, Andrew Michael Sovol
Bi-Planar Postural Stability Model: Fitting Parameters To Patient Data Automatically, Andrew Michael Sovol
Master's Theses (2009 -)
Studies of children with cerebral palsy (CP) have shown that maintaining control of posture in quiet standing is often difficult. Physical therapy and assistive devices, both with or without surgery, may be employed in an effort to improve postural stability. Assessing the effectiveness of such interventions is important for healthcare providers and their patients. A previously created bi-planar model of posture control has been further developed as a method of assessment. This MATLAB and Simulink model has successfully replicated experimental results for typical adults and children, as well as children with CP across three different test conditions: eyes open, eyes …
Upper Extremity Kinetics During Lofstrand Crutch-Assisted Gait In Children, Neha Bhagchandani
Upper Extremity Kinetics During Lofstrand Crutch-Assisted Gait In Children, Neha Bhagchandani
Master's Theses (2009 -)
Complete biomechanical analysis helps evaluate the motion during various gait patterns for the upper and lower extremities. Extensive studies have been performed to evaluate unassisted gait patterns, but very little has been accomplished for studying assisted motion. Children with pathologies such as osteogenesis imperfecta, spinal cord injury, and cerebral palsy use assistive devices such as anterior and posterior walkers, canes, Lofstrand and axillary crutches for ambulation purposes.
Statistics show that there are currently about 566,000 crutch users in the United States. The long-term crutch users in this population can suffer various upper limb pathologies associated with extensive upper extremity (UE) …