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Full-Text Articles in Biomedical Engineering and Bioengineering
Discriminatory Bio-Adhesion Over Nano-Patterned Polymer Brushes, Saugata Gon
Discriminatory Bio-Adhesion Over Nano-Patterned Polymer Brushes, Saugata Gon
Open Access Dissertations
Surfaces functionalized with bio-molecular targeting agents are conventionally used for highly-specific protein and cell adhesion. This thesis explores an alternative approach: Small non-biological adhesive elements are placed on a surface randomly, with the rest of the surface rendered repulsive towards biomolecules and cells. While the adhesive elements themselves, for instance in solution, typically exhibit no selectivity for various compounds within an analyte suspension, selective adhesion of targeted objects or molecules results from their placement on the repulsive surface. The mechanism of selectivity relies on recognition of length scales of the surface distribution of adhesive elements relative to species in the …
Tooth Cusp Radius Of Curvature As A Dietary Correlate In Primates, Michael Anthony Berthaume
Tooth Cusp Radius Of Curvature As A Dietary Correlate In Primates, Michael Anthony Berthaume
Open Access Dissertations
Tooth cusp radius of curvature (RoC) has been hypothesized to play an important role in food item breakdown, but has remained largely unstudied due to difficulties in measuring and modeling RoC in multicusped teeth. We tested these hypotheses using a parametric model of a four cusped, maxillary, bunodont molar in conjunction with finite element analysis. When our data failed to support existing hypotheses, we put forth and tested the Complex Cusp Hypothesis which states that, during brittle food items breakdown, an optimally shaped molar would be maximizing stresses in the food item while minimizing stresses in the enamel. After gaining …
Muscular Properties And Balance Control In Older Adults, Christopher James Hasson
Muscular Properties And Balance Control In Older Adults, Christopher James Hasson
Open Access Dissertations
The goal of this dissertation was to understand the role of age-related changes in muscle mechanical properties in the control of upright posture in humans. First, a methodology for estimating subject-specific muscle properties in healthy young and older individuals was developed. Magnetic resonance and ultrasound imaging were used in conjunction with dynamometer experiments, musculoskeletal modeling, and numerical optimization to estimate the properties of the dorsiflexor and individual plantarflexor (gastrocnemius and soleus) muscles for 12 young and 12 older adults (balanced for gender). With aging there were declines in maximal isometric strength and increases in series-elastic stiffness in the male subjects, …