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Theses/Dissertations

Mechanical Engineering Graduate Theses & Dissertations

Cervix

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Mechanical Failure Of Chorioamnion And Cervical Tissue: Contributions To Preterm And Term Birth, Brandi Nicole Briggs Jul 2014

Mechanical Failure Of Chorioamnion And Cervical Tissue: Contributions To Preterm And Term Birth, Brandi Nicole Briggs

Mechanical Engineering Graduate Theses & Dissertations

Despite significant advances in medical research, spontaneous preterm birth (SPTB) rates have not changed appreciably in over 100 years. SPTB is a global problem affecting 13 million babies annually and continues to be the leading cause of death among infants. During pregnancy, the cervix and chorioamnion (CA), the sac that surrounds the fetus during pregnancy, provide critical structural support for the growing fetus that requires optimum maintenance of tissue properties for sustaining pregnancy. This dissertation aims to elucidate the events leading to tissue failure in pregnancy by evaluating detrimental alterations in the extracellular matrix (ECM) chemistry and organization and tissue ...