Open Access. Powered by Scholars. Published by Universities.®

Biomedical Engineering and Bioengineering Commons

Open Access. Powered by Scholars. Published by Universities.®

Theses/Dissertations

Mechanical Engineering Graduate Theses & Dissertations

Cells

Articles 1 - 1 of 1

Full-Text Articles in Biomedical Engineering and Bioengineering

Engineering Complex Microenvironments For Directed Stem Cell Differentiation, Michael Louis Floren Jan 2015

Engineering Complex Microenvironments For Directed Stem Cell Differentiation, Michael Louis Floren

Mechanical Engineering Graduate Theses & Dissertations

Loss of vascular function associated with cardiovascular disease, such as arthrosclerosis, represents the leading medical epidemic in the United States and typically requires surgical intervention through synthetic or autologous vascular grafts. To overcome the limitations associated with adult cell sources, which are often restricted by supply or compromised by disease, mesenchymal stem cells (MSCs) have emerged as potential candidates for vascular tissue engineering. While evidence suggests the roles of several factors influencing MSC differentiation into vascular phenotypes, including matrix rigidity, geometry and chemistry, the phenomena associated with these events are still largely unknown. Further, the development of mature vascular phenotypes ...