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Theses/Dissertations

Mechanical Engineering Graduate Theses & Dissertations

Anisotropy

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Full-Text Articles in Biomedical Engineering and Bioengineering

Zonal Articular Cartilage Possesses Complex Mechanical Behavior Spanning Multiple Length Scales: Dependence On Chemical Heterogeneity, Anisotropy, And Microstructure, Joseph Anders Wahlquist Jan 2017

Zonal Articular Cartilage Possesses Complex Mechanical Behavior Spanning Multiple Length Scales: Dependence On Chemical Heterogeneity, Anisotropy, And Microstructure, Joseph Anders Wahlquist

Mechanical Engineering Graduate Theses & Dissertations

This work focused on characterizing the mechanical behavior of biological material in physiologically relevant conditions and at sub millimeter length scales. Elucidating the time, length scale, and directionally dependent mechanical behavior of cartilage and other biological materials is critical to adequately recapitulate native mechanosensory cues for cells, create computational models that mimic native tissue behavior, and assess disease progression. This work focused on three broad aspects of characterizing the mechanical behavior of articular cartilage. First, we sought to reveal the causes of time-dependent deformation and variation of mechanical properties with distance from the articular surface. Second, we investigated size dependence ...


Zonal Articular Cartilage Possesses Complex Mechanical Behavior Spanning Multiple Length Scales: Dependence On Chemical Heterogeneity, Anisotropy, And Microstructure, Joseph Anders Wahlquist Jan 2017

Zonal Articular Cartilage Possesses Complex Mechanical Behavior Spanning Multiple Length Scales: Dependence On Chemical Heterogeneity, Anisotropy, And Microstructure, Joseph Anders Wahlquist

Mechanical Engineering Graduate Theses & Dissertations

This work focused on characterizing the mechanical behavior of biological material in physiologically relevant conditions and at sub millimeter length scales. Elucidating the time, length scale, and directionally dependent mechanical behavior of cartilage and other biological materials is critical to adequately recapitulate native mechanosensory cues for cells, create computational models that mimic native tissue behavior, and assess disease progression. This work focused on three broad aspects of characterizing the mechanical behavior of articular cartilage. First, we sought to reveal the causes of time-dependent deformation and variation of mechanical properties with distance from the articular surface. Second, we investigated size dependence ...