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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Molecular Thermodynamics Of Superheated Lipid-Coated Fluorocarbon Nanoemulsions, Paul A. C. Mountford Jan 2015

Molecular Thermodynamics Of Superheated Lipid-Coated Fluorocarbon Nanoemulsions, Paul A. C. Mountford

Mechanical Engineering Graduate Theses & Dissertations

Diagnostic ultrasound is a safe, inexpensive and highly portable real-time imaging modality for viewing the human body. For over two decades, lipid-coated fluorocarbon microbubble contrast agents have been developed to help improve the diagnostic and therapeutic capabilities of ultrasound, but they have certain limitations. Recently, it was found that the microbubbles can be condensed into superheated liquid nanodrops capable of being vaporized by external optical or acoustic triggers. The compact form and vaporization effects of these phase-shift nanodrops may offer advantages over microbubbles for a number of current and future therapeutic and diagnostic applications. The goal of this dissertation work ...


Osteochondral Tissue Modeling Of Damage, Poroelastcity, And Remodeling In Osteoarthritis, Michael Eric Stender Jan 2015

Osteochondral Tissue Modeling Of Damage, Poroelastcity, And Remodeling In Osteoarthritis, Michael Eric Stender

Mechanical Engineering Graduate Theses & Dissertations

Arthritis is the most costly disability in the United States annually incurring billions of dollars in treatment costs and lost wages. Osteoarthritis, a classification of arthritis, affects articulating synovial joints (e.g., hip, knee, shoulder) and results in moderate to severe pain. In extreme cases, osteoarthritis causes loss of joint mobility. Presently, there is not a clear understanding of how osteoarthritis initiates, propagates, and ultimately degrades the mechanics of healthy synovial joints. This doctoral work uses computational modeling techniques and finite element analysis to elucidate the initiation and evolution of osteoarthritis with the ultimate goal of contributing to improved clinical ...


Experimental Analysis And Modeling Of Robot-Tissue Contact Mechanics For In Vivo Mobility, Levin John Sliker Jan 2015

Experimental Analysis And Modeling Of Robot-Tissue Contact Mechanics For In Vivo Mobility, Levin John Sliker

Mechanical Engineering Graduate Theses & Dissertations

Robotic mobility within the gastrointestinal (GI) tract is an intriguing concept, which has received wide attention from within the research community over the past ten years. Capsule endoscopes (CEs) exist commercially, but lack an active mobility system, rendering them as passive devices. These passive devices are only capable of observational procedures, and are limited by the passive speed (dependent on intestinal peristalsis), inability to control orientation, and vulnerability to retention, requiring surgical removal in severe cases. Additionally, passive capsules take photos throughout their journey, resulting in a compilation of thousands of images, which can take the attending physician hours to ...


Engineering Complex Microenvironments For Directed Stem Cell Differentiation, Michael Louis Floren Jan 2015

Engineering Complex Microenvironments For Directed Stem Cell Differentiation, Michael Louis Floren

Mechanical Engineering Graduate Theses & Dissertations

Loss of vascular function associated with cardiovascular disease, such as arthrosclerosis, represents the leading medical epidemic in the United States and typically requires surgical intervention through synthetic or autologous vascular grafts. To overcome the limitations associated with adult cell sources, which are often restricted by supply or compromised by disease, mesenchymal stem cells (MSCs) have emerged as potential candidates for vascular tissue engineering. While evidence suggests the roles of several factors influencing MSC differentiation into vascular phenotypes, including matrix rigidity, geometry and chemistry, the phenomena associated with these events are still largely unknown. Further, the development of mature vascular phenotypes ...