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Full-Text Articles in Biomedical Engineering and Bioengineering

Bioengineering Investigations Of Pulmonary Vascular Function In Pulmonary Hypertension: In Vivo, In Vitro And Modeling Studies, Lian Tian Apr 2010

Bioengineering Investigations Of Pulmonary Vascular Function In Pulmonary Hypertension: In Vivo, In Vitro And Modeling Studies, Lian Tian

Mechanical Engineering Graduate Theses & Dissertations

Pulmonary hypertension (PH) is characterized by chronic high blood pressure in the pulmonary arteries (PAs) and is an important cause of morbidity and mortality in children and adults. During the development of PH, the pulmonary circulation displays significant arterial remodeling, which yields changes in mechanical behavior and subsequently, of pulmonary vascular function (PVF). Recent clinical findings suggest that knowing the change in PVF is important for accurate prognosis of PH and its severity, and may be relevant in developing treatment strategies. One clinical effort has focused on the measurement of pulmonary vascular input impedance, which can provide comprehensive characterization of ...


Nanoindentation Of Bio- And Geo-Mineralized Composites: Contribution Of Microstructure And Composition, Sara E. Campbell Apr 2010

Nanoindentation Of Bio- And Geo-Mineralized Composites: Contribution Of Microstructure And Composition, Sara E. Campbell

Mechanical Engineering Graduate Theses & Dissertations

Bio-mineralized composite tissues, such as bone and teeth, are heterogeneous in both mineral composition and crystallinity. These tissues are altered throughout life by aging, wear, microfracture, and various disease states (e.g., osteoporosis), and are then further altered geologically after death by fossilization to create geo-mineralized tissues. Bone and enamel exhibit a wide range of mechanical responses at nanometer-length scales, where large-scale porosity and macro-structural variation are not factors. Some variability seen in mineralized tissues can be attributed to the amount of mineral; where a general increase in mechanical properties occurs with increasing mineral volume fraction. However, a large range ...


Biaxial Mechanical Characterization And Microstructure-Driven Modeling Of Elastic Pulmonary Artery Walls Of Large Mammals Under Hypertensive Conditions, Philip Hsien-Lan Kao Jan 2010

Biaxial Mechanical Characterization And Microstructure-Driven Modeling Of Elastic Pulmonary Artery Walls Of Large Mammals Under Hypertensive Conditions, Philip Hsien-Lan Kao

Mechanical Engineering Graduate Theses & Dissertations

Pulmonary Hypertension (PH) is a disease of the pulmonary vasculature which causes right heart failure. It is known that PH causes significant remodeling of the pulmonary arterial vasculature, but the effects of this remodeling are not well-understood. In addition, there is a dearth of research in large mammals for PH. Modeling of the arteries is also important in the simulation of deformation due to blood flow. Current models either do not reflect the microstructure, or are too complex for clinical use. This work presents mechanical characterization and analysis of the artery wall, in addition to a constitutive model driven by ...