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Biomedical Engineering and Bioengineering Commons

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Full-Text Articles in Biomedical Engineering and Bioengineering

Osteochondral Tissue Modeling Of Damage, Poroelastcity, And Remodeling In Osteoarthritis, Michael Eric Stender Jan 2015

Osteochondral Tissue Modeling Of Damage, Poroelastcity, And Remodeling In Osteoarthritis, Michael Eric Stender

Mechanical Engineering Graduate Theses & Dissertations

Arthritis is the most costly disability in the United States annually incurring billions of dollars in treatment costs and lost wages. Osteoarthritis, a classification of arthritis, affects articulating synovial joints (e.g., hip, knee, shoulder) and results in moderate to severe pain. In extreme cases, osteoarthritis causes loss of joint mobility. Presently, there is not a clear understanding of how osteoarthritis initiates, propagates, and ultimately degrades the mechanics of healthy synovial joints. This doctoral work uses computational modeling techniques and finite element analysis to elucidate the initiation and evolution of osteoarthritis with the ultimate goal of contributing to improved clinical ...


Mechanical Failure Of Chorioamnion And Cervical Tissue: Contributions To Preterm And Term Birth, Brandi Nicole Briggs Jul 2014

Mechanical Failure Of Chorioamnion And Cervical Tissue: Contributions To Preterm And Term Birth, Brandi Nicole Briggs

Mechanical Engineering Graduate Theses & Dissertations

Despite significant advances in medical research, spontaneous preterm birth (SPTB) rates have not changed appreciably in over 100 years. SPTB is a global problem affecting 13 million babies annually and continues to be the leading cause of death among infants. During pregnancy, the cervix and chorioamnion (CA), the sac that surrounds the fetus during pregnancy, provide critical structural support for the growing fetus that requires optimum maintenance of tissue properties for sustaining pregnancy. This dissertation aims to elucidate the events leading to tissue failure in pregnancy by evaluating detrimental alterations in the extracellular matrix (ECM) chemistry and organization and tissue ...


On The Generalization Of Decision-Making Preferences In Movement Under Risk, Megan Kathleen O'Brien Jan 2014

On The Generalization Of Decision-Making Preferences In Movement Under Risk, Megan Kathleen O'Brien

Mechanical Engineering Graduate Theses & Dissertations

Nearly every aspect of our behavior is framed by risk, and people can respond to risk very differently. Some individuals readily confront highly variable situations in order to obtain large rewards (risk-seeking behavior), while others prefer more certain situations even if it means obtaining smaller rewards (risk-averse behavior).

At present, the role that risk plays in movement decisions is poorly understood. This dissertation investigates human movement decisions under risk, exploring the rationality of movement behavior in risky constructs and whether sensitivity to risk generalizes across movements. In the first study, I compared risk-sensitivity between two continuous motor tasks (arm-reaching and ...