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Full-Text Articles in Biomedical Engineering and Bioengineering

Molecular Thermodynamics Of Superheated Lipid-Coated Fluorocarbon Nanoemulsions, Paul A. C. Mountford Jan 2015

Molecular Thermodynamics Of Superheated Lipid-Coated Fluorocarbon Nanoemulsions, Paul A. C. Mountford

Mechanical Engineering Graduate Theses & Dissertations

Diagnostic ultrasound is a safe, inexpensive and highly portable real-time imaging modality for viewing the human body. For over two decades, lipid-coated fluorocarbon microbubble contrast agents have been developed to help improve the diagnostic and therapeutic capabilities of ultrasound, but they have certain limitations. Recently, it was found that the microbubbles can be condensed into superheated liquid nanodrops capable of being vaporized by external optical or acoustic triggers. The compact form and vaporization effects of these phase-shift nanodrops may offer advantages over microbubbles for a number of current and future therapeutic and diagnostic applications. The goal of this dissertation work ...


Optically Active Plasmonic Microbubbles, Jacob Dove Jan 2014

Optically Active Plasmonic Microbubbles, Jacob Dove

Mechanical Engineering Graduate Theses & Dissertations

Contrast agents are used across a variety of medical imaging modalities for improved visualization of structures in the body. Microbubbles, for example, efficiently scatter ultrasound thereby providing enhanced ultrasonic imaging of the vasculature. Plasmonic nanoparticles, on the other hand, are efficient optical absorbers and can provide improvements in optical and photoacoustic imaging.

The focus of this thesis is on the development of novel contrast agents capable of enhancing both ultrasound and photoacoustic imaging modalities. The first agent is constructed by templating nanoparticles onto a lipid-encapsulated microbubble with a perfluorocarbon gas core. Using an avidin-biotin conjugation scheme, control over the nanoparticle ...


The Design And Evaluation Of A Pediatric Cardiothoracic Camera System For Identification And Repair Of Ventricular Septal Defects, Keir D. Hart Jan 2011

The Design And Evaluation Of A Pediatric Cardiothoracic Camera System For Identification And Repair Of Ventricular Septal Defects, Keir D. Hart

Mechanical Engineering Graduate Theses & Dissertations

Current detection of Ventricular Septal Defects (VSD) in pediatric patients can be difficult for hard to reach anatomy, such as apical defects, or for multiple VSDs. Existing technology such as Magnetic Resonance Imaging (MRI), catheterization, and echocardiography can be expensive, dangerous, or simply does not provide adequate images of these holes in the septal wall. Similarly, state of the art treatment practices have definitive limits in capability. Cardiac Transcatheterization and subsequent implantation of an occlusion device may not succeed as the occluder may be too close to heart valves or in relation to each other in the case of multiple ...