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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
Control Design And Implementation Of An Active Transtibial Prosthesis, Joseph Klein
Control Design And Implementation Of An Active Transtibial Prosthesis, Joseph Klein
Master's Theses (2009 -)
Prior work at Marquette University developed the Marquette Prosthesis, an active transtibial prosthesis that utilized a torsional spring and a four-bar mechanism. The controls for the Marquette Prosthesis implemented a finite state control algorithm to determine the state of gait of the amputee along with two lower level controllers, a PI moment controller to control the moment during stance and a PID position controller to control the position during stance. The Marquette Prosthesis was successful in mimicking the gait profile presented by Winter. However, after completing human subject testing, the Marquette Prosthesis was insufficient in trying to match the gait …
A Biomechanical Simulation Of Musculoskeletal Kinematics During Ambulation, Alex Thomas
A Biomechanical Simulation Of Musculoskeletal Kinematics During Ambulation, Alex Thomas
Master's Theses (2009 -)
The purpose of this study was to validate a 3D musculoskeletal model in OpenSim and assess OpenSim’s ability to determine muscle-length variation during ambulation. An 18 camera motion capture system was used to analyze 20 healthy individuals between the ages of 18 and 35. Following data collection, the data was processed through OpenSim and Visual3D. The kinematic output processed through the OpenSim model was then compared to the kinematic output of the validated Visual3D model to validate the OpenSim model. Muscle fiber length data obtained from the same experimental data was compared to control data to assess OpenSim’s muscle analysis …
Immersive Visualization In Biomedical Computational Fluid Dynamics And Didactic Teaching And Learning, John Thomas Venn
Immersive Visualization In Biomedical Computational Fluid Dynamics And Didactic Teaching And Learning, John Thomas Venn
Master's Theses (2009 -)
Virtual reality (VR) can stimulate active learning, critical thinking, decision making and improved performance. It requires a medium to show virtual content, which is called a virtual environment (VE). The MARquette Visualization Lab (MARVL) is an example of a VE. Robust processes and workflows that allow for the creation of content for use within MARVL further increases the userbase for this valuable resource. A workflow was created to display biomedical computational fluid dynamics (CFD) and complementary data in a wide range of VE’s. This allows a researcher to study the simulation in its natural three-dimensional (3D) morphology. In addition, it …
Investigation Of Reactive Oxygen Species Production In The Rat Lung Using Optical Imaging, Nina Friedly
Investigation Of Reactive Oxygen Species Production In The Rat Lung Using Optical Imaging, Nina Friedly
Master's Theses (2009 -)
Oxidative stress, the imbalance between production of oxidants or reactive oxygen species (ROS) and antioxidant activity, plays a key role in the pathogenesis of acute and chronic lung diseases. The objective of this thesis was to develop a robust protocol for measuring the rate of H2O2 production in isolated perfused rat lungs and to determine the cellular sources of that rate using Amplex Red (AR). For a given lung, AR (25 mM) along with horseradish peroxidase (5 U/ml) and ascorbate oxidase (1U/ml) were added to a perfusate reservoir that was recirculated through the lungs and sampled at 5 minute intervals …
Investigation Of The Effects Of Prosthetic Knee Condition On Novice Transfemoral Amputee Runners, Natalie Nelson
Investigation Of The Effects Of Prosthetic Knee Condition On Novice Transfemoral Amputee Runners, Natalie Nelson
Master's Theses (2009 -)
Some unilateral transfemoral amputees (TFAs) run in a prosthesis with an articulating prosthetic knee, others choose to run without a knee (prosthetic socket and foot are linked via a straight, non-articulating pylon) to increase stability. Research regarding unilateral TFA running with an unlocked versus locked prosthetic knee (approximately equivalent to the no-knee condition) with respect to energy cost and temporal metrics is limited; no studies have investigated the impact of knee condition on kinematic metrics. The purpose of this study was to investigate whether the prosthetic knee of a running-specific prosthesis (RSP) should be unlocked or locked for unilateral TFAs …
Pharmacokinetic Modeling Of 99mtc-Hmpao Images Of Isolated Perfused Rat Lungs, Katherine C. Barry
Pharmacokinetic Modeling Of 99mtc-Hmpao Images Of Isolated Perfused Rat Lungs, Katherine C. Barry
Master's Theses (2009 -)
The single-photon emission tomography (SPECT) imaging biomarker technetium-labeled hexamethylpropyleneamine oxime (99mTc-HMPAO) exists in two forms, the oxidized, cell-permeable form and the reduced, cell-impermeable form. Recent studies revealed that the lung uptake of 99mTc-HMPAO increases early in rat models of human acute lung injury. Lung uptake of 99mTc-HMPAO is the net result of multiple cellular and vascular processes, many of which can vary with acute illness. Thus, when a change in the lung uptake of 99mTc-HMPAO is detected, it is unclear how much of this change is due to alteration in the activity of the targeted cellular process versus alteration of …