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Biomedical Engineering and Bioengineering Commons™
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Full-Text Articles in Biomedical Engineering and Bioengineering
A Biomechanical Simulation Of Musculoskeletal Kinematics During Ambulation, Alex Thomas
A Biomechanical Simulation Of Musculoskeletal Kinematics During Ambulation, Alex Thomas
Master's Theses (2009 -)
The purpose of this study was to validate a 3D musculoskeletal model in OpenSim and assess OpenSim’s ability to determine muscle-length variation during ambulation. An 18 camera motion capture system was used to analyze 20 healthy individuals between the ages of 18 and 35. Following data collection, the data was processed through OpenSim and Visual3D. The kinematic output processed through the OpenSim model was then compared to the kinematic output of the validated Visual3D model to validate the OpenSim model. Muscle fiber length data obtained from the same experimental data was compared to control data to assess OpenSim’s muscle analysis …
Investigation Of Reactive Oxygen Species Production In The Rat Lung Using Optical Imaging, Nina Friedly
Investigation Of Reactive Oxygen Species Production In The Rat Lung Using Optical Imaging, Nina Friedly
Master's Theses (2009 -)
Oxidative stress, the imbalance between production of oxidants or reactive oxygen species (ROS) and antioxidant activity, plays a key role in the pathogenesis of acute and chronic lung diseases. The objective of this thesis was to develop a robust protocol for measuring the rate of H2O2 production in isolated perfused rat lungs and to determine the cellular sources of that rate using Amplex Red (AR). For a given lung, AR (25 mM) along with horseradish peroxidase (5 U/ml) and ascorbate oxidase (1U/ml) were added to a perfusate reservoir that was recirculated through the lungs and sampled at 5 minute intervals …