Biomedical Engineering and Bioengineering Commons^™

Computational Evaluation Of Shear Stress And Restenosis In Stented Coronary Arteries Using Optical Coherence Tomography, Joshua K. Hughey

Master's Theses (2009 -)

The cause of coronary artery neointimal thickness (NT) leading to restenosis in ~10% of drug-eluting stents (DES) is unknown, but adverse wall shear stress (WSS) may contribute. Prior studies comparing WSS to restenosis for first generation DES yielded conflicting results, and cited different mechanisms of action for DES agents. Studies to date have not accounted for stent geometry, which dictates local WSS patterns influencing drug concentration. The objective of this investigation was to evaluate current generation stent platforms via their WSS patterns and their respective impact on NT. We prospectively enrolled 19 patients, who were randomized to thin-strut (81μm) 2-link …