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Theses/Dissertations

Graduate Theses and Dissertations

Electric Fields

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Full-Text Articles in Biomedical Engineering and Bioengineering

Understanding The Role Of Colloidal Particles In Electroporation Mediated Delivery, Alisha Peterson Jan 2015

Understanding The Role Of Colloidal Particles In Electroporation Mediated Delivery, Alisha Peterson

Graduate Theses and Dissertations

Electroporation (EP) is a physical non-viral technique used to deliver therapeutic molecules across the cell membrane. During electroporation an external electric field is applied across a cell membrane and it causes pores to form. These pores then allow the surrounding media containing the therapeutics to diffuse across the membrane. This technique has been specifically studied as a promising gene and drug delivery system. Colloidal particles have also proven to be promising for a variety of biological applications including molecular delivery, imaging, and tumor ablation, due to their large surface area and tunable properties. In more recent years researchers have explored ...


Topography, Extracellular Matrix Proteins, Secreted Molecules And Endogenous Electric Fields: Cues That Influence The Differentiation Of Neural Progenitor Cells, Carlos Atico Ariza Jan 2009

Topography, Extracellular Matrix Proteins, Secreted Molecules And Endogenous Electric Fields: Cues That Influence The Differentiation Of Neural Progenitor Cells, Carlos Atico Ariza

Graduate Theses and Dissertations

Neural progenitor cells (NPCs) have the potential to be used as a cell based therapy to treat Alzheimer disease, spinal cord injury and other significant damage to the central nervous system. In order to utilize the therapeutic potential of NPCs, we must first learn to control their migration, proliferation, differentiation and growth. An ideal methodology would entail directed stem cell migration to damaged tissue; proliferation until the target is reached; differentiation into the most beneficial phenotype; and integration of cells into the existing tissue. A myriad of stimulants that alter NPC behavior, exist in vivo. Characterizing the individual contributions of ...