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Theses/Dissertations

Graduate Theses and Dissertations

Animal model

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Full-Text Articles in Biomedical Engineering and Bioengineering

Effects Of Body Temperature And General Anesthetics On Intraocular Pressure In Rats, Aditi Pillai Jun 2018

Effects Of Body Temperature And General Anesthetics On Intraocular Pressure In Rats, Aditi Pillai

Graduate Theses and Dissertations

Ocular hypertension has been identified as the fundamental risk factor in glaucoma which is the leading cause for irreversible blindness in the world. Understanding the different factors that affect IOP is of utmost importance in clinical management as IOP is considered as the fundamental factor in assessing the efficiency of glaucoma medications. Several studies have attempted to assess factors that could affect IOP including age, body position, blood pressure, anesthetics commonly used during eye operations, etc. However, in most of these studies IOP is measured under anesthesia using rodent models and these anesthetics could affect the IOP measurements directly or ...


Intraocular Pressure Sensing And Control For Glaucoma Research, Simon Antonio Bello Nov 2016

Intraocular Pressure Sensing And Control For Glaucoma Research, Simon Antonio Bello

Graduate Theses and Dissertations

Animal models of ocular hypertension are important for glaucoma research but come with experimental costs. Available methods of intraocular pressure (IOP) elevation are not always successful, the amplitude and time course of IOP changes are unpredictable and irreversible, and IOP measurement by tonometry is laborious. This dissertation focuses on the development and implementation of two novel systems for monitoring and controlling IOP without these limitations. The first device consists of a cannula implanted in the anterior chamber of the eye, a pressure sensor that continually measures IOP, and a bidirectional pump driven by control circuitry that can infuse or withdraw ...