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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Graduate Theses and Dissertations

2008

Photoluminescence

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Full-Text Articles in Biomedical Engineering and Bioengineering

Luminescent Water-Soluble Quantum Dots: Improved Stability Through Surface Functionalization, Manuela Aseye Ayele Ayee Jan 2008

Luminescent Water-Soluble Quantum Dots: Improved Stability Through Surface Functionalization, Manuela Aseye Ayele Ayee

Graduate Theses and Dissertations

Colloidally prepared semiconductor nanocrystal quantum dots (QDs) are inherently incompatible with biological systems because of the native hydrophobic molecules that coat their surfaces. Post-synthetic techniques such as ligand exchange and encapsulation are therefore employed to make them soluble in aqueous media while preserving their valuable properties such as bright photoluminescence and stability. Small hydrophilic organic molecules like dihydrolipoic acid and tris(hydroxypropyl)phosphine are used to displace the hydrophobic surface ligands, and derivatization by carbodiimide bioconjugation can enhance pH stability. Several QD encapsulation methods in polymer shells are covered, with the most promising one involving the use of a four-stream ...