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Full-Text Articles in Biomedical Engineering and Bioengineering

Corrosion Characteristics Of Magnesium Under Varying Surface Roughness Conditions, Yahya Efe Yayoglu Nov 2016

Corrosion Characteristics Of Magnesium Under Varying Surface Roughness Conditions, Yahya Efe Yayoglu

Graduate Theses and Dissertations

The biggest challenge with magnesium alloy biodegradable implants is the rapid corrosion at the earlier stages of the healing process after implantation. In this research, the impact of surface roughness generated by different means on the corrosion rate of AZ31 magnesium alloy in a simulated biologic environment is investigated. In order to perform accurate experimentation, an in vitro setup is assembled that simulates the human body environment accurately has been prepared using Schinhammer’s in vitro immersion testing setup and Kokubo’s Simulated Body Fluid (SBF). For the immersion test of Mg in SBF, several surface texture groups of Mg ...


Biomarker Detection At Risk Forecasting Level Using Metal-Enhanced Fluorescence Combined With Surface Acoustic Wave, Jun Liu Nov 2016

Biomarker Detection At Risk Forecasting Level Using Metal-Enhanced Fluorescence Combined With Surface Acoustic Wave, Jun Liu

Graduate Theses and Dissertations

In this paper, metal-enhanced fluorescence (MEF) technique is used to lower the detection limit of carcinoembryonic antigen (CEA) which is able to be utilized in forecasting the risk of having certain kinds of cancers, especially colon and rectal cancer. By incubating silver nanocubes (Ag NCs) on the surface of the chips, the detection limit goes down to below 1ng/mL of CEA. Also, when combining MEF with surface acoustic wave (SAW) devices, the incubation time between antigen and antibody will decrease significantly with the fluorescence signal keeping similar or higher level.


Assessing Viscoelastic Properties Of Polydimethylsiloxane (Pdms) Using Loading And Unloading Of The Macroscopic Compression Test, Mustafa Fincan Apr 2015

Assessing Viscoelastic Properties Of Polydimethylsiloxane (Pdms) Using Loading And Unloading Of The Macroscopic Compression Test, Mustafa Fincan

Graduate Theses and Dissertations

Polydimethylsiloxane (PDMS) mechanical properties were measured using custom-built compression test device. PDMS elastic modulus can be varied with the elastomer base to the curing agent ratio, i.e. by changing the cross-linking density. PDMS samples with different crosslink density in terms of their elastic modulus were measured. In this project the PDMS samples with the base/curing agent ratio ranging from 5:1 to 20:1 were tested. The elastic modulus varied with the amount of the crosslinker, and ranged from 0.8 MPa to 4.44 MPa. The compression device was modified by adding digital displacement gauges to measure ...


Understanding The Role Of Colloidal Particles In Electroporation Mediated Delivery, Alisha Peterson Jan 2015

Understanding The Role Of Colloidal Particles In Electroporation Mediated Delivery, Alisha Peterson

Graduate Theses and Dissertations

Electroporation (EP) is a physical non-viral technique used to deliver therapeutic molecules across the cell membrane. During electroporation an external electric field is applied across a cell membrane and it causes pores to form. These pores then allow the surrounding media containing the therapeutics to diffuse across the membrane. This technique has been specifically studied as a promising gene and drug delivery system. Colloidal particles have also proven to be promising for a variety of biological applications including molecular delivery, imaging, and tumor ablation, due to their large surface area and tunable properties. In more recent years researchers have explored ...


Biomaterial Testing Methodology For Long-Term In Vivo Applications: Silicon Carbide Corrosion Resistance, Biocompatibility And Hemocompatibility, Maysam Nezafati Jun 2014

Biomaterial Testing Methodology For Long-Term In Vivo Applications: Silicon Carbide Corrosion Resistance, Biocompatibility And Hemocompatibility, Maysam Nezafati

Graduate Theses and Dissertations

Biomedical devices that function in-vivo offer a tremendous promise to improve the quality of life for many who suffer from disease and trauma. The most important consideration for these devices is that they interact with the physiological environment as designed without initiating a deleterious inflammatory response. ISO 10993 outlines the current international guideline for investigating the biocompatibility of such devices. Numerous groups report the use of ISO 10993 as the basis for their experimental evaluation of candidate materials for neuroprosthetics, as well as other biomedical devices, however most of these reports fail to completely comply with the standard. This leads ...


Fabricating And Characterizing Physical Properties Of Electrospun Polypeptide-Based Nanofibers, Dhan Bahadur Khadka Jan 2013

Fabricating And Characterizing Physical Properties Of Electrospun Polypeptide-Based Nanofibers, Dhan Bahadur Khadka

Graduate Theses and Dissertations

This dissertation has aimed to fabricate polypeptide based biomaterial and characterize physical properties. Electrospinning is used as a tool for the sample fabrication. Project focused on determining the feasibility of electrospinning of certain synthetic polypeptides and certain elastin-like peptides from aqueous feedstocks and to characterize physical properties of polymer aqueous solution, cast film and spun fibers and fiber mats. The research involves peptide design, polymer electrospinning, fibers crosslinking, determining the extent of crosslinking, fibers protease degradation study, fibers stability and self-organization analysis, structure and composition determination by various spectroscopy and microscopy techniques and characterization of mechanical properties of individual suspended ...


Structured Materials For Catalytic And Sensing Applications, Selma Hokenek Jan 2013

Structured Materials For Catalytic And Sensing Applications, Selma Hokenek

Graduate Theses and Dissertations

The optical and chemical properties of the materials used in catalytic and sensing applications directly determine the characteristics of the resultant catalyst or sensor. It is well known that a catalyst needs to have high activity, selectivity, and stability to be viable in an industrial setting. The hydrogenation activity of palladium catalysts is known to be excellent, but the industrial applications are limited by the cost of obtaining catalyst in amounts large enough to make their use economical. As a result, alloying palladium with a cheaper, more widely available metal while maintaining the high catalytic activity seen in monometallic catalysts ...


Shape-Shifting Surfaces For Rapid Release And Direct Stamping Of Organized Micro-Tissues, Samuel James Dupont Jan 2012

Shape-Shifting Surfaces For Rapid Release And Direct Stamping Of Organized Micro-Tissues, Samuel James Dupont

Graduate Theses and Dissertations

The primary aim of the research in this study is to develop a robust and simple platform for the in vitro organization of cells on surfaces which facilitate rapid cell release and allows for the direct stamping of highly organized micro-tissues. Current approaches towards this goal have been very successful but are lengthy and subject cells to harsh conditions for extended periods of time raising questions regarding cell health and maintenance of physiological state. To address these concerns a platform was developed to allow for rapid cell release by utilizing a release mechanism different from previous work.

Micron-scale structures comprised ...


Materials Selection, Processing, And Manufacturing For A Design Of An Elbow Joint Replacement Prototype, Erik Manatt Jan 2012

Materials Selection, Processing, And Manufacturing For A Design Of An Elbow Joint Replacement Prototype, Erik Manatt

Graduate Theses and Dissertations

A new design for a canine elbow joint replacement was manufactured and assembled. The design incorporates a ceramic ball for articulation with radius and ulna components and a bioactive ceramic for tissue contact. A variety of materials were considered, with zirconia-toughened alumina selected as the wear surface, stainless steel as the structural backbone, and osteoceramic as the bioactive bone interface. The ceramic components were manufactured by cold isostatic pressing the powders, firing the formed rods to an intermediate temperature for strength, and then machining them before a final sintering. A modified osteoceramic bone cement with better flow characteristics was chosen ...