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Full-Text Articles in Biomedical Engineering and Bioengineering
Novel Magnetic Resonance Imaging-Compatible Mechatronic Needle Guidance System For Prostate Focal Laser Ablation Therapy, Eric R. Knull
Novel Magnetic Resonance Imaging-Compatible Mechatronic Needle Guidance System For Prostate Focal Laser Ablation Therapy, Eric R. Knull
Electronic Thesis and Dissertation Repository
Advances in prostate cancer (PCa) screening techniques have led to diagnosis of many cases of low-grade and highly localized disease. Conventional whole-gland therapies often result in overtreatment in such cases and debate still surrounds the optimal method of oncologic control. MRI-guided prostate focal laser ablation (FLA) is a minimally invasive treatment option, which has demonstrated potential to destroy localized lesions while sparing healthy prostatic tissue, thereby reducing treatment-related side effects. Many challenges still exist in the development of FLA, including patient selection; tumour localization, visualization, and characterization; needle guidance; and evaluation of treatment efficacy. The objective of this thesis work …
Computer-Assisted Characterization Of Prostate Cancer On Magnetic Resonance Imaging, Derek J. Soetemans
Computer-Assisted Characterization Of Prostate Cancer On Magnetic Resonance Imaging, Derek J. Soetemans
Electronic Thesis and Dissertation Repository
Prostate cancer (PCa) is one of the most prevalent cancers among men. Early diagnosis can improve survival and reduce treatment costs. Current inter-radiologist variability for detection of PCa is high. The use of multi-parametric magnetic resonance imaging (mpMRI) with machine learning algorithms has been investigated both for improving PCa detection and for PCa diagnosis. Widespread clinical implementation of computer-assisted PCa lesion characterization remains elusive; critically needed is a model that is validated against a histologic reference standard that is densely sampled in an unbiased fashion. We address this using our technique for highly accurate fusion of mpMRI with whole-mount …