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Full-Text Articles in Biomedical Engineering and Bioengineering
Pulmonary Imaging Of Chronic Obstructive Pulmonary Disease Using Multi-Parametric Response Maps, Jonathan Macneil
Pulmonary Imaging Of Chronic Obstructive Pulmonary Disease Using Multi-Parametric Response Maps, Jonathan Macneil
Electronic Thesis and Dissertation Repository
Chronic obstructive pulmonary disease (COPD) is characterized by irreversible airflow obstruction caused by airway remodelling and parenchymal destruction. Clinically, observation of COPD is performed using spirometry, but this technique only provides a global measure of lung health. To supplement these clinical measurements, thoracic computed tomography (CT) and hyperpolarized gas magnetic resonance imaging (MRI) have been used to measure regional structure and function abnormalities. Although CT and MRI have been used to research COPD, combination of both modalities into an interrelated image has never been performed. Therefore, we developed an image processing pipeline to combine MRI-CT information into a multi-parametric response …
A Heterogeneous Patient-Specific Biomechanical Model Of The Lung For Tumor Motion Compensation And Effective Lung Radiation Therapy Planning, Parya Jafari
Electronic Thesis and Dissertation Repository
Radiation therapy is a main component of treatment for many lung cancer patients. However, the respiratory motion can cause inaccuracies in radiation delivery that can lead to treatment complications. In addition, the radiation-induced damage to healthy tissue limits the effectiveness of radiation treatment. Motion management methods have been developed to increase the accuracy of radiation delivery, and functional avoidance treatment planning has emerged to help reduce the chances of radiation-induced toxicity. In this work, we have developed biomechanical model-based techniques for tumor motion estimation, as well as lung functional imaging. The proposed biomechanical model accurately estimates lung and tumor motion/deformation …
Quantitative Evaluation Of Pulmonary Emphysema Using Magnetic Resonance Imaging And X-Ray Computed Tomography, Amir M. Owrangi
Quantitative Evaluation Of Pulmonary Emphysema Using Magnetic Resonance Imaging And X-Ray Computed Tomography, Amir M. Owrangi
Electronic Thesis and Dissertation Repository
Chronic obstructive pulmonary disease (COPD) is a leading cause of morbidity and mortality affecting at least 600 million people worldwide. The most widely used clinical measurements of lung function such as spirometry and plethysmography are generally accepted for diagnosis and monitoring of the disease. However, these tests provide only global measures of lung function and they are insensitive to early disease changes. Imaging tools that are currently available have the potential to provide regional information about lung structure and function but at present are mainly used for qualitative assessment of disease and disease progression. In this thesis, we focused on …