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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Electronic Thesis and Dissertation Repository

Biomaterials

Biomaterials

2014

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Full-Text Articles in Biomedical Engineering and Bioengineering

Functional Co-Substituted Poly[(Amino Acid Ester)Phosphazene] Biomaterials, Amanda L. Baillargeon Jul 2014

Functional Co-Substituted Poly[(Amino Acid Ester)Phosphazene] Biomaterials, Amanda L. Baillargeon

Electronic Thesis and Dissertation Repository

The development of new and improved biomaterials is essential for tissue engineering and regenerative medicine applications. Amino acid-based polyphosphazenes are being explored as scaffold materials for tissue engineering applications due to their non-toxic degradation products and tunable material properties. This work focuses on the synthesis of non-functional and novel functional poly[(amino acid ester)phosphazene]s using a facile method of thermal ring opening polymerization followed by one-pot room temperature substitution. The family of polyphosphazenes developed in this work is based on L-alanine (PNEAs), L-phenylalanine (PNEFs), and L-methionine (PNEMs) with L-glutamic acid imparting the functionality. Characterization of these materials demonstrated ...