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Full-Text Articles in Biomedical Engineering and Bioengineering

Classifying And Predicting Walking Speed From Electroencephalography Data, Allen Rahrooh May 2019

Classifying And Predicting Walking Speed From Electroencephalography Data, Allen Rahrooh

Electronic Theses and Dissertations

Electroencephalography (EEG) non-invasively records electrocortical activity and can be used to understand how the brain functions to control movements and walking. Studies have shown that electrocortical dynamics are coupled with the gait cycle and change when walking at different speeds. Thus, EEG signals likely contain information regarding walking speed that could potentially be used to predict walking speed using just EEG signals recorded during walking. The purpose of this study was to determine whether walking speed could be predicted from EEG recorded as subjects walked on a treadmill with a range of speeds (0.5 m/s, 0.75 m ...


Fluctuations In Walking Speeds And Spatiotemporal Gait Parameters When Walking On A Self-Paced Treadmill At Level, Incline, And Decline Slopes, Cesar Castano May 2019

Fluctuations In Walking Speeds And Spatiotemporal Gait Parameters When Walking On A Self-Paced Treadmill At Level, Incline, And Decline Slopes, Cesar Castano

Electronic Theses and Dissertations

On a daily basis, humans walk over a variety of terrains. Studies have shown that spatiotemporal gait parameters, such as stride length, stride frequency, stride variability, etc., change when humans walk down a decline and up an incline compared to level ground. However, these studies have been limited to using fixed speed treadmills or analyzing a small number of strides when conducted over ground. Thus, there is a need to investigate the fluctuations in spatiotemporal gait parameters of humans walking at their self-selected speed, which requires recording hundreds of strides. Here we hypothesized that subjects will walk with a slower ...


Energy Expenditure And Stability During Self-Paced Walking On Different Slopes, Alanna Raffaelli May 2019

Energy Expenditure And Stability During Self-Paced Walking On Different Slopes, Alanna Raffaelli

Electronic Theses and Dissertations

Metabolic power and cost of transport (COT) are common quantifiers for effort when performing tasks including walking and running. Most studies focus on using a range of normal walking speeds over level ground or varied slopes. However, these studies use fixed-speed conditions. Fatigue, stability, metabolic expenditure, heart rate, and many other factors contribute to normal walking speed varying over time. This study aimed to show that allowing a subject to walk with a self-paced speed should correlate to a minimum COT at a given slope. This study also aimed to determine if a preferred slope exists based on minimizing metabolic ...


Conceptualization And Fabrication Of A Bioinspired Mobile Robot Actuated By Shape Memory Alloy Springs, Lietsel Richardson May 2019

Conceptualization And Fabrication Of A Bioinspired Mobile Robot Actuated By Shape Memory Alloy Springs, Lietsel Richardson

Electronic Theses and Dissertations

This work is an experimental study and fabrication of design concepts to validate the feasibility of smart materials and their applications in bio-inspired robotics. Shape-Memory Alloy (SMA) springs are selected as the smart material actuators of interest to achieve locomotion in the proposed mobile robot. Based on a previous design of the robot, this work focuses on both implementing a new locomotion concept and reducing size and weight of the previous design, both using SMA based actuators. Objectives are met in consideration of the conceptual mechanics of circular robot locomotion. The first prototype is a variation of the original design ...


Probing The Effects Of Substrate Stiffness On Astrocytes Mechanics, Ariege Bizanti Jan 2018

Probing The Effects Of Substrate Stiffness On Astrocytes Mechanics, Ariege Bizanti

Electronic Theses and Dissertations

Astrocytes are among the most functionally diverse population of cells in the central nervous system (CNS) as they are essential to many important neurological functions including maintaining brain homeostasis, regulating the blood brain barrier, and preventing build-up of toxic substances within the brain, for example. Astrocyte importance to brain physiology and pathology has inspired a host of studies focused on understanding astrocyte behavior primarily from a biological and chemical perspective. However, a clear understanding of astrocyte dysfunction and their link to disease has been hampered by a lack of knowledge of astrocyte behavior from a biomechanical perspective. Furthermore, astrocytes (and ...


Generation Of Recombinant Mouse Embryonic Stem Cell Lines And Theirapplication For In Vivo Bioluminiscence Imaging In The Heart, Ramana Kammili Jan 2008

Generation Of Recombinant Mouse Embryonic Stem Cell Lines And Theirapplication For In Vivo Bioluminiscence Imaging In The Heart, Ramana Kammili

Electronic Theses and Dissertations

Cardiovascular disease is the major cause of death in the United States, with 80 million people suffering from some form of heart disease each year. One major limitation is the inability of the heart to repair the damaged tissue. Stem cell therapy holds enormous promise to repair and regenerate the damaged myocardium, but there are many technical difficulties that must first be overcome. One such difficulty is the present lack of ability to track and assess transplanted stem cells over time in vivo. The central hypothesis of this thesis is that in vivo bioluminescence imaging is a safe and useful ...