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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

ETD Archive

2012

Keyword

Articles 1 - 10 of 10

Full-Text Articles in Biomedical Engineering and Bioengineering

Characterization Of Elastic-Like Polypeptide Micelles Using Capillary Viscometry, Sumit H. Kambow Jan 2012

Characterization Of Elastic-Like Polypeptide Micelles Using Capillary Viscometry, Sumit H. Kambow

ETD Archive

Elastin-like polypeptides (ELPs) are a part of the family of responsive polymers. These polymers can be made to respond to a wide variety of stimuli, including temperature, pH, salt, concentration, light, and solvent. Elastin-like polypeptides are soluble in water at low temperatures but they become hydrophobic and insoluble above their transition temperature. Elastin-like polypeptides, (GVGVP)40-foldon and (GVGVP)60-foldon, were expressed in bacterial system. These ELPs above their transition temperature, Tt, at low salt (< 45mM) and high pH (> pH 10) assemble into micelles where the hydrophobic tails phase separate in the interior of the micelle as an immiscible coacervate phase. The oligomerization domain termed ...


7d Cardiac Flow Mri: Techniques & Automation Of Reconstruction, Michael G. Ambrosia Jan 2012

7d Cardiac Flow Mri: Techniques & Automation Of Reconstruction, Michael G. Ambrosia

ETD Archive

Advances in magnetic resonance imaging to quantify the blood flow in the heart and major vessels stemming from the heart has recently allowed for advanced clinical applications for patients suffering from cardiac valve problems and aortic abnormalities. 7D cardiac flow quantification is relatively new, but has already shown potential in several clinical applications, including bicuspid valve and aortic coarctation characterization. In addition radiologists diagnosing valvular regurgitation may benefit from insight provided by the 7D cardiac flow quantification protocol. 7D cardiac flow quantification using magnetic resonance imaging will provide direction flow quantification in the anterior / posterior, head / foot, and left / right ...


Effects Of Magnesium Sulfate, Digestate And Other Inorganic Nutrients On The Phototrophic Growth Of The Green Microalga Scenedesmus Dimorphus, Jacob R. Schwenk Jan 2012

Effects Of Magnesium Sulfate, Digestate And Other Inorganic Nutrients On The Phototrophic Growth Of The Green Microalga Scenedesmus Dimorphus, Jacob R. Schwenk

ETD Archive

The individual components of the growth media, notably magnesium, have a profound impact on the growth and lipid production of the green microalgae, Scenedesmus dimorphus. The goal of this work was to investigate these effects and explain the causes via multiple experiments. It is important to understand the aspects of algal growth because they have a significant impact on the commercial viability of microalgal lipids as a potential feedstock for biofuel production. Digestate, derived from bovine waste and a potential cost effective nutrient replacement for conventional media types, was found to maximize growth and lipid concentration in S. dimorphus at ...


Effect Of Glucose Supplementation On Nighttime Biomass Loss And Productivity Of Microalgae Chlorella, Dhruvesh Shah Jan 2012

Effect Of Glucose Supplementation On Nighttime Biomass Loss And Productivity Of Microalgae Chlorella, Dhruvesh Shah

ETD Archive

Microalgae have been proven to be a promising source for the production of biofuel. It has higher oil yield than any other food crop. Oil yield from microalgae is 7 to 13 times higher than the best food crop. There are several issues to be addressed for economic production of biofuel from microalgae. One such issue is cultivation of microalgae. Algae can be cultivated photoautotrophically or heterotrophically. Algae grown photoautotrophically lose up to 35 of the biomass during nighttime. Heterotrophic cultivation of microalgae has been proven to be resulting in faster microalgae production compared to photoautotrophic growth, but requires use ...


In Vitro Biomechanical Testing And Computational: Modeling In Spine, Mageswaran Prasath Jan 2012

In Vitro Biomechanical Testing And Computational: Modeling In Spine, Mageswaran Prasath

ETD Archive

Two separate in vitro biomechanical studies were conducted on human cadaveric spines (Lumbar) to evaluate the stability following the implantation of two different spinal fixation devices interspinous fixation device (ISD) and Hybrid dynamic stabilizers. ISD was evaluated as a stand-alone and in combination with unilateral pedicle rod system. The results were compared against the gold standard, spinal fusion (bilateral pedicle rod system). The second study involving the hybrid dynamic system, evaluated the effect on adjacent levels using a hybrid testing protocol. A robotic spine testing system was used to conduct the biomechanical tests. This system has the ability to apply ...


Myocardial T1 Mapping Techniques For Quantification Of Myocardial Fibrosis, Xiaopeng Zhou Jan 2012

Myocardial T1 Mapping Techniques For Quantification Of Myocardial Fibrosis, Xiaopeng Zhou

ETD Archive

Identifying and quantifying diffuse myocardial fibrosis is important to provide insights into the relationship between myocardial fibrosis, diastolic and systolic dysfunction, as well as clinical outcomes. T1 mapping is a promising technique for noninvasively identifying diffuse myocardial fibrosis in heart failure. A quantitative T1 map provides sensitivity to the full range of T1 values and is advantageous over the traditional T1-weighted imaging by reducing the reliance on visual interpretation of the signal intensity in the myocardium. However, in-vivo myocardial T1 quantification is challenging because of cardiac and respiratory motion. During the past few years, a variety of T1 mapping techniques ...


Modification Of Behavior Of Elastin-Like Polypeptides By Changing Molecular Architecture, Ali Ghoorchian Jan 2012

Modification Of Behavior Of Elastin-Like Polypeptides By Changing Molecular Architecture, Ali Ghoorchian

ETD Archive

Elastin-like polypeptides (ELP) are environmentally responsive polymers that exhibit phase separation in response to external stimuli such as temperature, pH, light, and ionic strength. It has been shown that the sequence of the pentapeptide, its length, and the solution concentration are very important in the transition of the molecules from soluble to insoluble, but there has not been any detailed study of the effect of molecular architecture on the behavior of ELPs.In this study we designed, synthesized and characterized ELPs with different architectures and chemical identities to probe the effect of molecular design on the microscopic and macroscopic behavior ...


Controlled Delivery Of Tgf-ß1 From Plga Nanoparticles, Pratik K. Vaidya Jan 2012

Controlled Delivery Of Tgf-ß1 From Plga Nanoparticles, Pratik K. Vaidya

ETD Archive

Abdominal aortic aneurysms (AAAs) typically manifest as localized wall weakening and dilation of the infrarenal aorta, which grows gradually, and ultimately leads to fatal rupture. It is caused due to overexpression of proteolytic enzymes (matrix metalloproteases or MMPs) resulting into disruption of tissue structure, especially elastic matrix, which cannot be regenerated by adult vascular cells. On account of post-operative complications associated with their surgical repair, there is a critical need for developing non-surgical strategies for slowing and even regressing AAA growth. Recent studies in our laboratory have demonstrated that 1 ng/mL of transforming growth factor-β1 (TGF-β1) enhances regenerative repair ...


Elastogenic Characterization Of Rat Bm-Msc-Derived Smcs Towards Use In Soft Tissue Engineering, Sahithya Wintrich Jan 2012

Elastogenic Characterization Of Rat Bm-Msc-Derived Smcs Towards Use In Soft Tissue Engineering, Sahithya Wintrich

ETD Archive

No abstract provided.


Analysis Of Microstructure And Macrosegregation For Directional Solidification Of Al-7 Wt Si Alloy With A Cross-Section Change At Growth Speeds Of 10 And 29.1 [Mu]M/S, Luke Johnson Jan 2012

Analysis Of Microstructure And Macrosegregation For Directional Solidification Of Al-7 Wt Si Alloy With A Cross-Section Change At Growth Speeds Of 10 And 29.1 [Mu]M/S, Luke Johnson

ETD Archive

No abstract provided.