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Biomedical Engineering and Bioengineering Commons™
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Articles 1 - 11 of 11
Full-Text Articles in Biomedical Engineering and Bioengineering
Characterization Of Changes In Hyaluronan Following Epidermal Barrier Injury In An Organotypic Model, Gati Ajani
Characterization Of Changes In Hyaluronan Following Epidermal Barrier Injury In An Organotypic Model, Gati Ajani
ETD Archive
The stratum corneum, the outermost layer of the epidermis of skin, provides a functional permeability barrier that is essential for our survival and must be rapidly repaired after injury. Of interest to us, a ubiquitous matrix molecule called hyaluronan (HA) has come to the forefront in wound healing research because it is induced after epidermal injury and may be crucial for barrier repair. This thesis examines the role of HA during recovery from the most fundamental form of skin injury, i.e. selective damage to the stratum corneum. The overall question is whether this form of stratum corneum injury can lead …
Novel Antifreeze Protein Constructs For Improved Activity, Ozge Can
Novel Antifreeze Protein Constructs For Improved Activity, Ozge Can
ETD Archive
Many organisms are exposed to subzero temperatures in nature and can survive these temperatures by the effect of antifreeze proteins (AFPs), which inhibit ice crystal growth and change the morphology of ice crystals. Although the effects of these proteins, such as recrystallization inhibition, ice growth inhibition, and crystal habit changes, are known, a conclusive description of the protein-ice crystal interaction including interaction energy, surface coverage, and lifetime of adsorbate has been elusive. In this study, different antifreeze protein constructs are designed and expressed such that they can be conjugated to polymers to increase the thermal hysteresis activity especially at low …
Fabrication Of Nanostructured Metals And Their Hydrogen Storage Properties, Asli Ertan
Fabrication Of Nanostructured Metals And Their Hydrogen Storage Properties, Asli Ertan
ETD Archive
Searching for new energy sources is highly desirable for the next generations when rapidly changing factors are considered such as population, increasing pollution and exhaustion of fossil fuels. Hence, there is a need for clean, safe and efficient energy carriers or forms of energy that can be transported to the end user. One of these energy carriers is electricity which has been used widely and can be produced from various sources. However, its production from fossil fuels contributes to pollution. On the other hand hydrogen, due to its abundance, light weight, low mass density, high energy density and non-polluting nature …
The Development Of An In Vivo Spinal Fusion Monitor Using Microelectromechanical (Mems) Technology To Create Implantable Microsensors, Lisa Anne Ferrara
The Development Of An In Vivo Spinal Fusion Monitor Using Microelectromechanical (Mems) Technology To Create Implantable Microsensors, Lisa Anne Ferrara
ETD Archive
Surgical fusion of the spine is a conventional approach, and often last alternative, to the correction of a degenerative painful spinal segment. The procedure involves the surgical removal of the intervertebral disc at the problematic site, and the placement of a bone graft that is commonly harvested from the patients iliac crest and placed within the discectomized space. The surrounding bone is expected to incorporate and remodel into the bone graft to eventually provide an immobilized site. Spinal instrumentation often accompanies the bone graft to provide further immobility to the targeted site, thus augmenting the fusion process. However, the status …
Relationship Between Arch Height And Midfoot Joint Pressures During Gait, Dong Gil Lee
Relationship Between Arch Height And Midfoot Joint Pressures During Gait, Dong Gil Lee
ETD Archive
A foot arch is a multi-segmented curved structure which acts as a spring during locomotion. It is well known that ligaments are important components contributing to this spring-like property of the arch. In addition, intrinsic and extrinsic foot muscles contribute to arch support. According to the windlass foot model, arch height and midfoot joint orientation change during gait. However, it is not known whether altered joint configurations result in increased joint stress during gait. If so, it is possible for there to be a "vicious cycle" in which joint stress increases as the arch height diminishes, which may then lead …
Mems (Micro-Electro-Mechanical-Systems) Based Microfluidic Platforms For Magnetic Cell Separation, Pulak Nath
Mems (Micro-Electro-Mechanical-Systems) Based Microfluidic Platforms For Magnetic Cell Separation, Pulak Nath
ETD Archive
Microfluidic platforms for magnetic cell separation were developed and investigated for isolation of magnetic particles and magnetically tagged cells from a fluidic sample. Two types of magnetic separation platforms were considered: an Isodynamic Open Gradient Magnetic Sorter (OGMS) and a multistage bio-ferrograph. Miniaturized magnets were designed using magnetostatic simulation software, microfluidic channels were fabricated using microfabrication technology and magnetic separation was investigated using video microscopy and digital image processing. The isodynamic OGMS consisted of an external magnetic circuit and a microfabricated channel (biochip) with embedded magnetic elements. The biochip is placed inside the magnetic field of the external circuit to …
A Novel Cardiac Pacing Paradigm For Atrial Fibrillation And Heart Failure Patients, George Emanuel Yanulis
A Novel Cardiac Pacing Paradigm For Atrial Fibrillation And Heart Failure Patients, George Emanuel Yanulis
ETD Archive
It has been estimated that 4.6 million persons have heart failure, and 400,000 to 700,000 new cases develop each year and the U.S. Hospital discharges for HF rose from 399,000 in 1979 to 1,099,000 in 2004 according to the National Hospital Discharge Survey. Atrial fibrillation is the most common sustained cardiac arrhythmia in the United States. Recent studies have demonstrated that ventricular rate control is a viable treatment strategy for patients in atrial fibrillation. In a number of cases, despite the electrical resynchronization of the ventricles using biventricular pacing (cardiac resynchronization therapy), heart failure patients in sinus rhythm do not …
Bio-Signal Analysis In Fatigue And Cancer Related Fatigue;Weakening Of Corticomuscular Functional Coupling, Qi Yang
ETD Archive
Fatigue is a common experience that reduces productivity and increases chance of injury, and has been reported as one of most common symptoms with greatest impact on quality-of-life parameters in cancer patients. Neural mechanisms behind fatigue and cancer related fatigue (CRF) are not well known. Recent research has shown dissociation between changes in brain and muscle signals during voluntary muscle fatigue, which may suggest weakening of functional corticomuscular coupling (fCMC). However, this weakening of brain-muscle coupling has never been directly evaluated. More important information could be gained if fCMC is directly detected during fatigue because a voluntary muscle contraction depends …
Biocompatibility Of Osteoblast Cells On Titanium Implants, Dilip Ayyala Somayajula
Biocompatibility Of Osteoblast Cells On Titanium Implants, Dilip Ayyala Somayajula
ETD Archive
Adhesion and proliferation of UMR 106-01 osteoblast cells were studied on various surface modified titanium materials such as polished, sandblasted, anodized and alkaline treated. Anodization of polished surface in Hydrofluoric acid developed nano-tubes, while NaOH treatment produced spongy microporous morphology. Test samples were coated with non-adhesive protein bovine serum albumin and compared with fibronectin coated specimens. The adhesion study lasted for 4 hrs, where osteoblast cells were cultured in serum free medium. Polished titanium, anodized titanium and NaOH titanium have shown similar percentages of cell adherence. The proliferation study lasted for 48 hrs, where cells were initially allowed to adhere …
Slurry Based Coatings On Silicon Based Ceramics, Sameer K. Khaja-Abdul
Slurry Based Coatings On Silicon Based Ceramics, Sameer K. Khaja-Abdul
ETD Archive
The use of advanced structural ceramics, such as Si3N4 (SN282), SiC, and SiC/SiC composites, is a promising technology to accomplish the high performance goals for advanced turbine applications. These materials exhibit excellent corrosion resistance by forming a dense silica scale. However, severe degradation of the silica scale has been observed due to the presence of certain environmental species, like alkali salts and water vapors, limiting the long-term reliability of structural ceramics. Presence of water vapor in the turbine environment leads to the formation of a gaseous silicon hydroxide species (Si(OH)4) via a reaction with silica layer, SiO2(s) + 2H2O(g) = …
Nonlinear State Estimation In Polymer Electrolyte Membrane Fuel Cells, Uma Tumuluri
Nonlinear State Estimation In Polymer Electrolyte Membrane Fuel Cells, Uma Tumuluri
ETD Archive
Research on alternative and renewable energy sources which are amicable to the environment has gained momentum because of the growing concern about the tremendous increase in the concentration of toxic and green house gases and scarcity of the fossil fuels. Among the available renewable sources, fuel cell technology has received a high research attention due to their high efficiency and superior reliability. Among the various fuel cells available, Polymer electrolyte membrane fuel cell is promising source for both stationary and mobile applications because of its high efficiency and low operating temperatures. The performance of the fuel cell depends on the …