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The Effect Of Elastin Degradation On The Biomechanical Properties Of Porcine Aortic Tissue, Caleb Nissen
The Effect Of Elastin Degradation On The Biomechanical Properties Of Porcine Aortic Tissue, Caleb Nissen
Biomedical Engineering Undergraduate Honors Theses
The rupture of abdominal aortic aneurysms (AAA) is currently the 13th leading cause of death in the United States [1]. AAA is characterized, in part, by an increase in presence of proteolytic enzymes which degrade the structural proteins collagen and elastin [6]. The goal of this study was to examine the effect that elastin degradation has on the biomechanical properties of aortic tissue. For this experiment, porcine aortic tissue was cut in the circumferential and longitudinal directions. These specimens were exposed to an elastase solution for varying time-intervals and then underwent uniaxial tensile testing. Elastase-treated tissue tested in the …