Biomedical Engineering and Bioengineering Commons^™

Spectral And Temporal Interrogation Of Cerebral Hemodynamics Via High Speed Laser Speckle Contrast Imaging, Rex Chin-Hao Chen

Theses and Dissertations

Laser Speckle Contrast Imaging (LSCI) is a non-scanning wide field-of-view optical imaging technique specifically developed for cerebral blood flow (CBF) monitoring. In this project, a versatile Laser speckle contrast imaging system has been designed and developed to monitor CBF changes and examine the physical properties of cerebral vasculature during functional brain activation experiments.

The hardware of the system consists of a high speed CMOS camera, a coherent light source, a trinocular microscope, and a PC that does camera controlling and data storage. The simplicity of the system’s hardware makes it suitable for biological experiments.

In controlled flow experiments using a …