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Theses/Dissertations

University of Tennessee, Knoxville

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Articles 1 - 30 of 113

Full-Text Articles in Biomedical Engineering and Bioengineering

Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock May 2019

Final Design Report For The Bioburden Pre-Cleaning Device And Dr. Mark Rasnake At The University Of Tennessee Medical Center, Katherine Elizabeth Stiles, Megan Pitz, Kayla Franklin, Simran Dayal, Austin Bullock

Chancellor’s Honors Program Projects

No abstract provided.


Design And Synthesis Of Analogs Of Myo-Inositol, Serine, And Cysteine To Enable Chemical Biology Studies, Tanei J. Ricks Dec 2017

Design And Synthesis Of Analogs Of Myo-Inositol, Serine, And Cysteine To Enable Chemical Biology Studies, Tanei J. Ricks

Doctoral Dissertations

Phosphorylated myo-inositol compounds including inositol phosphates (InsPs) as well as the phosphatidylinositol polyphosphate lipids (PIPns) are critical biomolecules that regulate many of the most important biological processes and pathways. They are aberrant in many disease states due to their regulatory function. The same is true of the phospholipid phosphatidylserine (PS) which can serve as a marker to begin apoptosis. However, the full scope of activities of these structures is not clear, particularly since techniques that enable global detection and analysis of the production of these compounds spatially and temporally are lacking. With all of these obstacles in ...


Managing Exoelectrogenic Microbial Community Development Through Bioprocess Control For Conversion Of Biomass-Derived Streams, Alex James Lewis Aug 2017

Managing Exoelectrogenic Microbial Community Development Through Bioprocess Control For Conversion Of Biomass-Derived Streams, Alex James Lewis

Doctoral Dissertations

Bioelectrochemical systems are an emerging technology capable of utilizing aqueous waste streams generated during biomass conversion of lignocellulosic feedstocks to produce valuable co-products and thus, have potential to be integrated into biorefineries. In a microbial electrolysis cell, organic compounds are converted to electrons, protons, and CO2 by fermentative and exoelectrogenic bacteria in the anode compartment. By having the ability to extract electrons from waste streams, these systems can treat water while also producing hydrogen, and thus can improve the efficiency of biomass to fuel production by minimizing external hydrogen requirement and enabling water recycle. The overall goal of this ...


Development And Implementation Of A Forward Solution Hip Mathematical Model To Determine In Vivo Mechanics And Predict Hip Separation, Michael Thomas Lacour Aug 2017

Development And Implementation Of A Forward Solution Hip Mathematical Model To Determine In Vivo Mechanics And Predict Hip Separation, Michael Thomas Lacour

Doctoral Dissertations

Osteoarthritis, signified by excessive wear of joint cartilage, is most common in hip, knee, and spinal joints [1]. Current treatment for extreme osteoarthritis is total joint arthroplasty, where the damaged bone and cartilage are removed and replaced by artificial bone representations separated by artificial cartilage representations. While this treatment does generally improve patient quality of life, current joint replacement systems unfortunately still yield atypically high forces, premature component wear, and abnormal kinematics compared to native joints [2] [3] [4] [5].

For total hip arthroplasty, one common complication is in vivo separation and dislocation of the femoral head within the acetabular ...


Crafting Nanostructured Neural Interfaces With Hydrogel Particles, Emily Ann Morin Aug 2017

Crafting Nanostructured Neural Interfaces With Hydrogel Particles, Emily Ann Morin

Doctoral Dissertations

Central nervous system neural device functionality hinges on effective communication with surrounding neurons. This depends on both the permissiveness of the device material to promote neuron integration and the ability of the device to avoid a chronic inflammatory response. Here, a facile approach has been developed exploring the multiple functionalities of hydrogel particles to provide cues to impart neural integration for such materials. Three distinct, yet interconnected tasks were undertaken: investigating hydrogel particle-modified substrate neuron integration and central nervous system inflammatory response, investigating guided hydrogel particle adsorption, and investigating hydrogel particles as local reservoirs for counteracting adverse effects from oxidative ...


Design Of A Robotic Instrument Manipulator For Endoscopic Deployment, Ryan Ponten Aug 2017

Design Of A Robotic Instrument Manipulator For Endoscopic Deployment, Ryan Ponten

Masters Theses

This thesis describes the initial design process for an application of continuum robotics to endoscopic surgical procedures, specifically dissection of the colon. We first introduce the long-term vision for a benchtop dual-instrument endoscopic system with intuitive haptic controllers and then narrow our focus to the design and testing of the instrument manipulator itself, which must be actuated through the long, winding channel of a standard colonoscope.

Based on design requirements for a target procedure, we analyze simulations of two types of continuum robots using recently established kinematic and mechanic modeling approaches: the concentric-tube robot (CTR) and the concentric agonist-antagonist robot ...


Dynamic Simulation And Analysis Of Gait Modification For Treating Knee Osteoarthritis, Taylor Elyse Schlotman May 2017

Dynamic Simulation And Analysis Of Gait Modification For Treating Knee Osteoarthritis, Taylor Elyse Schlotman

Doctoral Dissertations

Roughly 47.5 million people in the US have a disability, with 8.6 million reporting arthritis as their main cause of disability, making arthritis the leading cause of physical disability. With decreased mortality rates and a large, aging baby boomer generation, there will be more adults living with chronic musculoskeletal conditions causing disabilities that limit walking. Since walking ability is directly related to an individual’s independence at home and in the community, losing this ability is a major setback for patients with arthritis. Knee osteoarthritis (OA) is the most prevalent form of arthritis affecting approximately 27 million adults ...


Characterization And Manipulation Of Lipid Self-Assembly To Construct Stable, Portable Synthetic Lipid Bilayers, Guru Anand Venkatesan May 2017

Characterization And Manipulation Of Lipid Self-Assembly To Construct Stable, Portable Synthetic Lipid Bilayers, Guru Anand Venkatesan

Doctoral Dissertations

The overarching goal of this research work is to further our understanding of lipid self-assembly and its organization at an oil-water interface to support the development of synthetic lipid bilayer systems that can be used in biologically relevant fields such as membrane biophysics, protein electrophysiology, development of synthetic biomolecules, drugs, nanoparticles and other applications. Self-assembly kinetics and interfacial properties of lipid monolayers formed at a liquid-air and liquid-liquid interface are characterized using Langmuir-Blodgett trough and pendant drop tensiometer. Insights gained from these studies not only allow us to answer questions related to droplet interface bilayer (DIB; a promising technique to ...


High-Throughput Functional System For Encapsulated Networks Of Model Cell Membranes, Mary-Anne Kim Anh Nguyen May 2017

High-Throughput Functional System For Encapsulated Networks Of Model Cell Membranes, Mary-Anne Kim Anh Nguyen

Doctoral Dissertations

Synthetic lipid bilayers provide models of cell membranes to study biomolecular interactions and signal transduction. The droplet interface bilayer (DIB) is a highly versatile technique for assembling planar lipid membranes between water droplets in oil. The DIB method thus provides a unique capability for developing digital, droplet-based membrane platforms for rapid membrane characterization, drug screening and ion channel recordings. In this work, a new microfluidic system is presented that automates droplet generation, sorting, and sequential trapping in designated locations to enable rapid assembly of arrays of DIBs along with in situ electrical measurements. This platform provides repeatable processes for forming ...


Musculoskeletal Loads During Stationary Cycling And The Effects Of Pedal Modifications For Knee Osteoarthritis, Rachel Lynn Thompson May 2017

Musculoskeletal Loads During Stationary Cycling And The Effects Of Pedal Modifications For Knee Osteoarthritis, Rachel Lynn Thompson

Doctoral Dissertations

Knee OA is a deteriorating joint disease affecting 27 million people in the US and current exercise prescriptions may be improved with new knowledge of their effects on muscle forces and joint contact loads. Cycling rather than other exercise modalities is generally considered an alternative for people with knee OA. If these research objectives were achieved, clinicians would have additional tools related to joint contact loads for treating people with OA with an cycling exercise while controlling progression of OA. The long-term goal of this research is to provide a scientific basis for planning, evaluation and improvement of subject-specific rehabilitation ...


Phototherapy Mounting System For Inpatient Rehabilitation, Kelsey Henderson, Elizabeth Fortunato, Jacob Dixon May 2017

Phototherapy Mounting System For Inpatient Rehabilitation, Kelsey Henderson, Elizabeth Fortunato, Jacob Dixon

Chancellor’s Honors Program Projects

No abstract provided.


Modeling, Analysis, Force Sensing And Control Of Continuum Robots For Minimally Invasive Surgery, Caroline Bryson Black May 2017

Modeling, Analysis, Force Sensing And Control Of Continuum Robots For Minimally Invasive Surgery, Caroline Bryson Black

Doctoral Dissertations

This dissertation describes design, modeling and application of continuum robotics for surgical applications, specifically parallel continuum robots (PCRs) and concentric tube manipulators (CTMs). The introduction of robotics into surgical applications has allowed for a greater degree of precision, less invasive access to more remote surgical sites, and user-intuitive interfaces with enhanced vision systems. The most recent developments have been in the space of continuum robots, whose exible structure create an inherent safety factor when in contact with fragile tissues. The design challenges that exist involve balancing size and strength of the manipulators, controlling the manipulators over long transmission pathways, and ...


Final Design Report For The Gastrointestinal Anastomosis Device And Lawrence Lee, Md, University Heart Surgeons, Sara Parker, Chloe O'Dell, M Jake Potter, Jordan Failla May 2017

Final Design Report For The Gastrointestinal Anastomosis Device And Lawrence Lee, Md, University Heart Surgeons, Sara Parker, Chloe O'Dell, M Jake Potter, Jordan Failla

Chancellor’s Honors Program Projects

No abstract provided.


An Economic Evaluation Of A Biofuel Supply Chain Utilizing Multiple Feedstocks, Huaqi Zhang Dec 2016

An Economic Evaluation Of A Biofuel Supply Chain Utilizing Multiple Feedstocks, Huaqi Zhang

Masters Theses

Biomass is considered as one potential feedstock for biofuel production. However, the high cost of biomass-to-biofuel supply chain, attributed to biomass’s low bulk density and resulting harvest, storage, and transportation challenges, has been a major hindrance to the success of biomass-based biofuel industry. In addition, the issue of dry matter losses during storage for a feedstock has affected biomass quantity and quality if the feedstock is stored for several months after a single harvest in a year. One potential way to improve the economics of biomass supply chain is to reduce storage need and enhance the utilization of harvest ...


Fluorochlorozirconate Glass Ceramics For Computed Radiography, Adam Wesley Evans Aug 2016

Fluorochlorozirconate Glass Ceramics For Computed Radiography, Adam Wesley Evans

Masters Theses

Heat treating fluorochlorozirconate (FCZ) glasses nucleates nanocrystals in the glass matrix, resulting in a glass ceramic that has optical properties suitable for use as a medical imaging plate. As the temperature of heat treatment rises, the resulting FCZ glass-ceramic becomes increasingly more opaque as the size of the orthorhombic phase BaCl­2[barium chloride] nanocrystals grow within the glass matrix. This opaqueness negatively affects imaging. The effect of adding Fe3+[iron] on the valence state of zirconium and overall glass quality was investigated.

Samples were synthesized and characterized with differential scanning calorimetry to determine the temperature of the orthorhombic ...


Next Generation In-Vivo Forward Solution Physiological Model Of The Human Lower Limb To Predict Implanted Knee Mechanics, Bradley Allen Meccia Aug 2016

Next Generation In-Vivo Forward Solution Physiological Model Of The Human Lower Limb To Predict Implanted Knee Mechanics, Bradley Allen Meccia

Doctoral Dissertations

Current total knee arthroplasty (TKA) evaluation methods are both time consuming and expensive. They require fabrication of the TKA and then utilize a wear or cadaveric simulator which does not necessarily replicate in-vivo conditions. Other analysis methods involve following the long-term success of TKA in subjects for five or more years. Mathematical modeling of TKA provide an efficient method at a greatly reduced cost for evaluating TKA. Obviously, the accuracy of a mathematical model is extremely important to the validity of the results.

Mathematical modeling of the knee faces many difficulties. The number of muscles actuating the knee is much ...


A Feasibility Study Of Just-In-Time Asthma Self-Management Intervention, Phillip Charles Scruggs Aug 2016

A Feasibility Study Of Just-In-Time Asthma Self-Management Intervention, Phillip Charles Scruggs

Masters Theses

Quality asthma care requires not only an initial diagnosis, but long term follow up care and education on long term control. Preventable symptoms continue to reduce the quality of life for chronic asthma sufferers and place an unnecessary burden on emergency services and the health care system at large. A mobile health (mHealth) solution is proposed to effectively improve outcomes for patients while ultimately reducing the overall burden of mismanagement on the healthcare system as a whole. The Just-in-Time Asthma Self- Management and Intervention (JASMIN) system provides a way for a patient or user to track, self-manage, and interact with ...


Improving Droplet Interface Bilayers As Models For Cell Membranes, Graham Jeffery Taylor May 2016

Improving Droplet Interface Bilayers As Models For Cell Membranes, Graham Jeffery Taylor

Doctoral Dissertations

This work describes research aimed at improving the droplet interface bilayer (DIB) platform for creating and characterizing biologically relevant model cell membranes. Improvements are made possible in part through the development of a portable, compact platform for controlling temperature with DIBs. Feedback-controlled heating allows studies to be conducted across a range of temperatures, from ambient up to at least 80°C, and also provides new understanding of methods to form DIBs using mixtures of total lipids extracted from bacterial and eukaryotic cells. The membranes formed from total lipid extracts (TLE) are introduced along with evidence that model membranes formed using ...


Inter-Droplet Membranes For Mechanical Sensing Applications, Nima Tamaddoni Jahromi May 2016

Inter-Droplet Membranes For Mechanical Sensing Applications, Nima Tamaddoni Jahromi

Doctoral Dissertations

This dissertation combines self-assembly phenomena of amphiphilic molecules with soft materials to create and characterize mechanoelectrical transducers and sensors whose sensing elements are thin-film bioinspired membranes comprised of phospholipids or amphiphilic polymers. We show that the structures of these amphiphilic molecules tune the mechanical and electrical properties of these membranes. We show that these properties affect the mechanoelectrical sensing characteristic and range of operation of these membrane transducers. In the experiments, we construct and characterize a membrane-based hair cell embodiment that enables the membrane to be responsive to mechanical perturbations of the hair. The resulting oscillations of membranes formed between ...


In Silico Driven Metabolic Engineering Towards Enhancing Biofuel And Biochemical Production, Richard Adam Thompson May 2016

In Silico Driven Metabolic Engineering Towards Enhancing Biofuel And Biochemical Production, Richard Adam Thompson

Doctoral Dissertations

The development of a secure and sustainable energy economy is likely to require the production of fuels and commodity chemicals in a renewable manner. There has been renewed interest in biological commodity chemical production recently, in particular focusing on non-edible feedstocks. The fields of metabolic engineering and synthetic biology have arisen in the past 20 years to address the challenge of chemical production from biological feedstocks. Metabolic modeling is a powerful tool for studying the metabolism of an organism and predicting the effects of metabolic engineering strategies. Various techniques have been developed for modeling cellular metabolism, with the underlying principle ...


Lost And Found: Use Of Gps Technology To Improve Storage Of Patient Belongings In Hospital Setting, Shelby A. Sievers, Griffin M. Heise, Min G. Kang, Michael Totty May 2016

Lost And Found: Use Of Gps Technology To Improve Storage Of Patient Belongings In Hospital Setting, Shelby A. Sievers, Griffin M. Heise, Min G. Kang, Michael Totty

Chancellor’s Honors Program Projects

No abstract provided.


A Comparative Study On Calcification Of Aortic Valves, Shirin Masjedi May 2016

A Comparative Study On Calcification Of Aortic Valves, Shirin Masjedi

Doctoral Dissertations

Calcific Aortic Valve Disease (CAVD) is a major disorder in the developed countries among elderly. It is characterized by calcific deposition and stiffening of the aortic valve cusps. CAVD is a highly cell-mediated condition where valvular interstitial cells (VICs) become activated and differentiate into osteoblast-like cells. This is associated with upregulation of calcific markers like Alkaline phosphatase (ALP) and Runx2. ECM remodeling in another characteristic of stenotic aortic valves due to VIC activation. Reports show that CAVD initiates majorly on the noncoronary side of the aortic valves. Additionally, male sex is a significant risk factor of CAVD. Aortic valves are ...


Adaptive Kernel Estimation For Enhanced Filtering And Pattern Classification Of Magnetic Resonance Imaging: Novel Techniques For Evaluating The Biomechanics And Pathologic Conditions Of The Lumbar Spine, Nicholas Vincent Battaglia May 2016

Adaptive Kernel Estimation For Enhanced Filtering And Pattern Classification Of Magnetic Resonance Imaging: Novel Techniques For Evaluating The Biomechanics And Pathologic Conditions Of The Lumbar Spine, Nicholas Vincent Battaglia

Doctoral Dissertations

This dissertation investigates the contribution the lumbar spine musculature has on etiological and pathogenic characteristics of low back pain and lumbar spondylosis. This endeavor necessarily required a two-step process: 1) design of an accurate post-processing method for extracting relevant information via magnetic resonance images and 2) determine pathological trends by elucidating high-dimensional datasets through multivariate pattern classification. The lumbar musculature was initially evaluated by post-processing and segmentation of magnetic resonance (MR) images of the lumbar spine, which characteristically suffer from nonlinear corruption of the signal intensity. This so called intensity inhomogeneity degrades the efficacy of traditional intensity-based segmentation algorithms. Proposed ...


Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet May 2016

Wheelchair Fatigue Reducer, Aaron Miller, Dennis Andre Norfleet

Chancellor’s Honors Program Projects

No abstract provided.


Magnetism Of Magnetite Nanoparticles As Determined By Mössbauer Spectroscopy, Hien-Yoong Hah May 2016

Magnetism Of Magnetite Nanoparticles As Determined By Mössbauer Spectroscopy, Hien-Yoong Hah

Masters Theses

Fe3O4 [Magnetite] nanoparticles have magnetism that differs greatly from their bulk counterparts. Whereas bulk Fe3O4 is a ferrimagnet, single-domain Fe3O4 nanoparticles have been found to be superparamagnetic. This allows for increased magnetization of the nanoparticles compared to the bulk when in a magnetic field. For most paramagnets, magnetization requires applied fields of a few Tesla at low temperatures. This is achievable through the application of superconducting magnets. In superparamagnets, the high susceptibility of the particles allows magnetization through a Nd-Fe-B permanent magnet at room temperature. This is caused by an increased ...


Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford Dec 2015

Icloudecg: A Mobile Cardiac Telemedicine System, David S. Clifford

Masters Theses

With rising healthcare costs and a substantially growing number of patients 65 or over, the benefits of telemedicine and patient self-monitoring systems are becoming increasingly evident. Patients, physicians, hospitals, and even insurance providers benefit from vigilant, cost-effective patient monitoring systems. This thesis describes the development of a portable, smart-phone connected system for continuous cardiac monitoring. The system is capable of continuously monitoring the conditions of the heart, automated detection of cardiac arrhythmias, and real-time notifying patients and physicians of the detected abnormalities. The system consists of four main subsystems: 1) a Bluetooth capable chest-strap ECG, 2) an Android-enabled mobile device ...


Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez Dec 2015

Removal Of Trace Organic Compounds In Domestic Wastewater Using Recirculating Packed-Bed Media Filters, Brittani Nikole Perez

Masters Theses

Pharmaceuticals and personal care products (PPCPs) are commonly detected in the environment resulting from their survival from conventional wastewater treatment systems. More information is needed about the fate and transfer of these trace organic compounds in domestic wastewater and their associated risks so that efficient strategies for their removal can be developed for both large/small scale treatment systems. This study aimed to determine whether onsite wastewater treatment systems were capable of providing PPCP removal, in addition to quantifying different forms of removal (biodegradation/sorption). A column study was constructed to determine the removal efficiencies of 3 target PPCPs, endocrine ...


Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen Dec 2015

Effects Of Varus Knee Alignment And Using Toe-Cages On Frontal Plane Knee Biomechanics In Stationary Cycling, Guangping Shen

Masters Theses

Effects of varus knee alignment on the internal knee abduction moment (KAM) in walking has been widely studied. KAM has been shown to be closely associated with the development of medial knee osteoarthritis (OA). Despite the importance of the knee alignment, no studies have explored its effects on knee frontal plane biomechanics during stationary cycling. The purpose of this study was to examine the effects of varus knee alignment and using a toe-cage on the knee frontal plane biomechanics during stationary cycling. Eleven participants in each of the varus and neutral groups participated in the study. The participants performed in ...


Fluorochlorozirconate Glass Ceramics For Photovoltaic And Computed Radiography Applications, Russell Lee Leonard Aug 2015

Fluorochlorozirconate Glass Ceramics For Photovoltaic And Computed Radiography Applications, Russell Lee Leonard

Doctoral Dissertations

Fluorochlorozirconate (FCZ) glass ceramics are versatile materials whose optical properties may be tuned through compositional or processing changes. For this work, FCZ glasses were synthesized, and then subsequently heat treated to create optically-active glass ceramics. The glasses and glass ceramics were characterized using a number of methods including differential scanning calorimetry, phosphorimetry, x-ray diffraction, and spectrophotometry. Samples were evaluated for applications in photovoltaics and computed radiography–especially those pertaining to intraoral dental radiography and portal imaging.

The ability of FCZ glass ceramics containing hexagonal barium chloride nanocrystals doped with the rare earth elements, holmium and europium, to downshift ultraviolet light ...


A Magnetic Actuated Fully Insertable Robotic Camera System For Single Incision Laparoscopic Surgery, Xiaolong Liu Aug 2015

A Magnetic Actuated Fully Insertable Robotic Camera System For Single Incision Laparoscopic Surgery, Xiaolong Liu

Doctoral Dissertations

Minimally Invasive Surgery (MIS) is a common surgical procedure which makes tiny incisions in the patients anatomy, inserting surgical instruments and using laparoscopic cameras to guide the procedure. Compared with traditional open surgery, MIS allows surgeons to perform complex surgeries with reduced trauma to the muscles and soft tissues, less intraoperative hemorrhaging and postoperative pain, and faster recovery time. Surgeons rely heavily on laparoscopic cameras for hand-eye coordination and control during a procedure. However, the use of a standard laparoscopic camera, achieved by pushing long sticks into a dedicated small opening, involves multiple incisions for the surgical instruments. Recently, single ...