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Theses/Dissertations

University of Denver

Modeling

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Full-Text Articles in Biomedical Engineering and Bioengineering

Finite Element Modeling Of Patient-Specific Total Shoulder Arthroplasty, Ignacio Rivero Crespo Aug 2023

Finite Element Modeling Of Patient-Specific Total Shoulder Arthroplasty, Ignacio Rivero Crespo

Electronic Theses and Dissertations

Total Shoulder Arthroplasty (TSA) is a surgical procedure designed to improve joint functionality by replacing the articulation between the humeral head and the glenoid fossa. Anatomic Total Shoulder Arthroplasty (aTSA) and Reverse Total Shoulder Arthroplasty (rTSA) are two types of replacement surgery to relieve pain and restore function of the shoulder. The overall goal of this study was to evaluate the effects of variation of certain patient and implant alignment parameters that may influence long-term outcomes of these surgical procedures, including kinematics, joint loads and contact mechanics. Computational models of six TSA subjects, three aTSA and three rTSA, were created …


Statistical Shape Modeling To Quantify Variation In The Proximal Humeral Anatomy, Paul B. Sade Sr. Jan 2017

Statistical Shape Modeling To Quantify Variation In The Proximal Humeral Anatomy, Paul B. Sade Sr.

Electronic Theses and Dissertations

The fit of the humeral prosthesis to the intramedullary canal and the replication of the anatomic humeral head center are important factors in Total Shoulder Arthroplasty (TSA). The objective of this thesis was to develop a Statistical Shape Model (SSM) of the cortical and cancellous bone regions of the proximal humerus, and to assess potential shape differences with gender and ethnicity, with a goal of informing implant design. An SSM was used and Principal Component Analysis (PCA) was applied to data that represented both the cancellous and cortical humeral bone of 63 healthy subjects and cadavers. Anatomical measurements and PC …


Specimen-Specific Natural, Pathological, And Implanted Knee Mechanics Using Finite Element Modeling, Azhar Akber Ali Jan 2017

Specimen-Specific Natural, Pathological, And Implanted Knee Mechanics Using Finite Element Modeling, Azhar Akber Ali

Electronic Theses and Dissertations

There is an increasing incidence of knee pain and injury among the population, and increasing demand for higher knee function in total knee replacement designs. As a result, clinicians and implant manufacturers are interested in improving patient outcomes, and evaluation of knee mechanics is essential for better diagnosis and repair of knee pathologies. Common knee pathologies include osteoarthritis (degradation of the articulating surfaces), patellofemoral pain, and cruciate ligament injury and/or rupture. The complex behavior of knee motion presents unique challenges in the diagnosis of knee pathology and restoration of healthy knee function. Quantifying knee mechanics is essential for developing successful …


Multiscale Musculoskeletal Modeling Of The Lower Limb To Perform Personalized Simulations Of Movement, Alessandro Navacchia Jan 2016

Multiscale Musculoskeletal Modeling Of The Lower Limb To Perform Personalized Simulations Of Movement, Alessandro Navacchia

Electronic Theses and Dissertations

Computational modeling has been used for many decades to inform design and decision-making in several fields of engineering, such as aerospace, automotive, petroleum, and others. However, it still struggles to have a similar impact in fields of medicine, such as orthopaedics. Three of the challenges that have limited the use of computational modeling in the clinical practice and in product development are model validation, personalization, and realism. Validation is a challenge because several internal parameters of the human body, such as muscle forces, are not safely measurable in vivo and, consequently, a thorough comparison between model outputs …