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Biomedical Engineering and Bioengineering Commons™
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- Normal Human Dermal Fibroblast cells (2)
- APTES (1)
- Active Sound Suppression (1)
- Bacterial Cellulose (1)
- Bacterial cellulose (1)
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- Gelatin (1)
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- MPTMS (1)
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- Nerve growth factor (1)
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- Optic nerve crush (1)
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- PEG-DA (1)
- PEG-LA-DA (1)
- Passive Sound Suppression (1)
- Photogrammetry (1)
- Poly(ethylene glycol) (1)
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- Surface modification (1)
- Tissue engineering (1)
Articles 1 - 5 of 5
Full-Text Articles in Biomedical Engineering and Bioengineering
Development Of Entubulation Strategies For Treating Central Nervous System Injuries, Ivy Brosch
Development Of Entubulation Strategies For Treating Central Nervous System Injuries, Ivy Brosch
Williams Honors College, Honors Research Projects
According to the McKnight Brain Institute, at least 10,000 people annually in the USA suffer from a central nervous system (CNS) injury. These injuries can cause serve disabilities including paralysis. Due to the complexity of the spinal cord, it is common that potential CNS treatments are first applied to an optic nerve crush (ONC) model in rats. Two proposed treatments were employed; one where nerve growth factor (NGF) was immobilized to a chitosan substrate to stimulate axonal regeneration, and the other using pentadecafluorooctanoyl chloride modified methacrylamide chitosan (MAC(Ali15)F) hydrogel to enhance local oxygenation. The two different treatments were formed into …
Modification Of Bacterial Cellulose Using Organosilanes To Enhance Cell Adhesion And Growth, Kristi Ferrato
Modification Of Bacterial Cellulose Using Organosilanes To Enhance Cell Adhesion And Growth, Kristi Ferrato
Williams Honors College, Honors Research Projects
In this project, drying bacterial cellulose (BC) to maintain its structural integrity, and treating BC with organosilanes 3-aminopropyltriethoxysilane (APTES) and (3-Mercaptopropyl)trimethoxysilane (MPTMS) as well as with various concentration of gelatin to increase the cells per area was studied. Drying BC with hexamethyldisilazane (HMDS) by soaking the BC in ascending concentrations of ethanol and HMDS did not protect the structural integrity of the BC grown in lab but did for the BC grown in Dr. Siriporn Taokaew’s lab. Freeze drying also did not fully protect the structural integrity as the BC was placed in a freezer for several hours at -20oC …
Molded Features In Pdms For Fabricating Bacterial Cellulose For Various Geometries, Mitchell Habegger
Molded Features In Pdms For Fabricating Bacterial Cellulose For Various Geometries, Mitchell Habegger
Williams Honors College, Honors Research Projects
The purpose of producing features on bacterial cellulose (BC) is to facilitate the elongation and alignment for cells, in this case Normal Human Dermal Fibroblast (NHDF) cells. The elongated cells have applications in wound healing, tissue engineering, disease diagnostics, and many other fields. Experiments were run to test the effectiveness of transferring features to BC sheets from features induced by fracturing on polydimethylsiloxane (PDMS) and those duplicated from molds with existing features. The features were duplicated to BC sheets by either air drying or Guided Assembly-Based Biolithography (GAB). The research results showed that fracture inducing on PDMS produced very small …
Wearable Hearing Accessory Technology, Tyler Cindea, Jaime Alcorn, Brooke Draper, Kyle Glascott, Ben Hanna, Robert Thoerner
Wearable Hearing Accessory Technology, Tyler Cindea, Jaime Alcorn, Brooke Draper, Kyle Glascott, Ben Hanna, Robert Thoerner
Williams Honors College, Honors Research Projects
We set out in August 2017 to develop an active noise suppressing device that would be usable both in military and civilian activities. Due to constraints in knowledge and time, we decided our best course of action was to divide the project into two equal projects with the hope to be able to combine them into a single project at the end of the allotted time. This consisted of an active noise suppression device and a passive noise suppression device. The passive device would have no electronic components and the active device would be pure circuitry with no housing. This …
Degradability Of Poly(Ethylene) Based Microgels And Methods Of Improving High Polydispersity Index, Abrar Alniemi
Degradability Of Poly(Ethylene) Based Microgels And Methods Of Improving High Polydispersity Index, Abrar Alniemi
Williams Honors College, Honors Research Projects
In order to improve upon the utilization of poly(ethylene glycol) (PEG) microgel-based scaffolds in drug delivery applications, this work explores the use of degradable and non-degradable PEG for tunable scaffolds. Previously, issues concerning the required uniformity in microgel size and low polydispersity index have been encountered. As such, methods of refining polymer synthesis, microgel fabrication, and microgel size separation were explored. Overall, no solution has been found to correct the issue for the microgels were still observed to have high polydispersity index regardless of varied troubleshooting alterations.