Biomedical Engineering and Bioengineering Commons^™

Motor Data Scaling By Respiration Frequencies In Rest, Amit Madhukar Kamble

Theses

Functional Magnetic Resonance Imaging (fMRI) is widely used as a tool to see activations in the different brain regions. Motor data acquired from fMRI scan is accompanied with signal due to hemodynamic changes taking place during the scan. This hemodynamic signal is dominated by parameter alteration in the large vessels of brain. Scaling of task induced BOLD signal with hypercapnic or breathold data is one of the effective methods to minimize the signal due to large vessels. Patient discomfort and compliance has been a major issue with these methods hence in this study we used respiration frequencies in rest data …

Application Of Bootstrap Resampling In Fmri, Arthika Bappal

Theses

This thesis demonstrates the use of the bootstrap resampling technique considering temporal dependency in the fMRI data to determine the reliability and confidence interval of fMRI parameters. Traditionally, the test-retest method has been used to reliably detect active voxels in the fMRI image of the brain, which is based on repetitive experimentation. The main concern with the test-retest method is the reproducibility of data over these multiple repetitions. Fatigue, habituation, motion artifacts, and repositioning errors are few of the factors, which can affect the reproducibility of data.

The conventional bootstrap resampling technique is based on the assumption that the dataset …

Development Of Fmri Compatible Lower Body Negative Pressure System, Pratap Singh Kunwar

Theses

The lower body negative pressure (LBNP) system provides a controlled, measured orthostatic stress to the cardiovascular system, which can be used with a magnetic resonance imaging (MRI) machine to study cardiovascular and cerebrovascular responses to graded LBNP. In the past, even though functional MRI (fMRI) was considered as one of the best modalities with which to measure small metabolic changes in the brain, it has not been used with an LBNP system to measure cerebrovascular changes. This was due to the lack of an fMRI compatible LBNP system.

In this project, an tMRI compatible LBNP system was first constructed without …