Biomedical Engineering and Bioengineering Commons^™

Development And Characterization Of An In-House Custom Bioreactor For The Cultivation Of A Tissue Engineered Blood-Brain Barrier, Amin Hadi Mirzaaghaeian

Master's Theses

The development of treatments for neurological disorders such as Alzheimer’s and Parkinson’s disease begins by understanding what these diseases affect and the consequences of further manifestation. One particular region where these diseases can produce substantial problems is the blood-brain barrier (BBB). The BBB is the selective diffusion barrier between the circulating blood and the brain. The barrier’s main function is to maintain CNS homeostasis and protect the brain from the extracellular environment. The progression of BBB research has advanced to the point where many have modeled the BBB in vitro with aims of further characterizing and testing the barrier. Particularly, …

A Novel In-House Design Of A Bioreactor For The Modeling Of An In Vitro Blood Brain Barrier Model, Ian Mahaffey

Biomedical Engineering

The blood brain barrier is the protector of the central nervous system and a physical barrier that functions to regulate the substances that can pass in and out of the brain; it is the function and integrity of this system that keeps the homeostasis of the central nervous system. Yet this shield against foreign invaders in the blood also prevents drugs designed for treatment of various ailments of the central nervous system from reaching their target in the brain. Developing drugs that can pass through this barrier, and understanding it’s function has become an area of increasing interest. Many researchers …

Mammary Epithelial Cell Growth On A Three-Dimensional Scaffold In An Operating Bioreactor, Melissa Marie Davalle

Master's Theses

Mammary epithelial cells are highly efficient secreting cells. With genetic engineering, the uses of these cells could be endless. Research is being conducted on these cells to determine their full potential to the biotech industry.

This paper investigates whether bovine epithelial mammary cells can survive in glutaraldehyde-treated gelatin tubes in an operating bioreactor. Many bioreactors were developed and tested to suit the needs of the cells. Procedures were created and carried out to ensure sterility of the bioreactors. Bovine mammary epithelial cells were implanted in the bioreactors and samples of their growth were taken over time.

Implementation Of Physiologic Pressure Conditions In A Blood Vessel Mimic Bioreactor System, Kevin Mark Okarski

Master's Theses

ABSTRACT

Implementation of Physiologic Pressure Conditions in a Blood Vessel Mimic Bioreactor System

Kevin Mark Okarski

Tissue engineering has traditionally been pursued as a therapeutic science intended for restoring or replacing diseased or damaged biologic tissues or organs. Cal Poly’s Blood Vessel Mimic Laboratory is developing a novel application of tissue engineering as a tool for the preclinical evaluation of intravascular devices. The blood vessel mimic (BVM) system has been previously used to assess the tissue response to deployed stents, but under non-physiologic conditions. Since then, efforts have been made to improve the vessel and bioreactor’s ability to emulate in …

Design And Optimization Of A Blood Vessel Mimic Bioreactor System For The Evaluation Of Intravascular Devices In Simple And Complex Vessel Geometries, Sara M. Leifer

Master's Theses

Coronary artery disease affects millions of people and the ability to detect and treat the disease is advancing at a rapid rate. As a result, the development of intravascular technologies is the focus of many medical device manufacturers. Specifically, coronary stent implantation is being performed in an increasing number of patients and a number of new stent designs have been introduced to the market, resulting in the need for improved preclinical testing methods. An in vitro tissue engineered “blood vessel mimic” (BVM) system has previously been established and its feasibility for the initial testing of newly emerging intravascular technology has …