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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

California Polytechnic State University, San Luis Obispo

Angiogenesis

2010

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Full-Text Articles in Biomedical Engineering and Bioengineering

Immunohistochemical Mapping Of Hypoxia In Ischemic Mouse Hindlimb Skeletal Muscle, Emily Deckert Aug 2010

Immunohistochemical Mapping Of Hypoxia In Ischemic Mouse Hindlimb Skeletal Muscle, Emily Deckert

Biomedical Engineering

The study of blood vessel growth and remodeling is a complex endeavor. Hypoxia, the lack of oxygen in a tissue, is known to stimulate angiogenesis (the growth of new blood vessels), and have little effect on arteriogenesis (the enlargement of existing blood vessels). However, the role of hypoxia in vessel function is unknown, but may be determined using the results and methods developed in this experiment.

Supplied by the bloodstream, oxygen is required by all cells and tissues to remain healthy. If the bloodstream supplying a certain tissue with blood is disrupted, the tissue becomes ischemic, often leading to hypoxia ...