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Theses/Dissertations

California Polytechnic State University, San Luis Obispo

2014

Arteriogenesis

Articles 1 - 4 of 4

Full-Text Articles in Biomedical Engineering and Bioengineering

Smooth Muscle Cell Organization In The Stem Region Of The Gracilis Collateral Circulation In Balb/C Mice, Laura Lenae Burckhardt Dec 2014

Smooth Muscle Cell Organization In The Stem Region Of The Gracilis Collateral Circulation In Balb/C Mice, Laura Lenae Burckhardt

Biomedical Engineering

Of the approximately 8 million Americans who suffer from ischemic peripheral arterial occlusive disease (PAOD), many present with intermittent claudication, or pain associated with exercise. Impaired vasodilation of resistance vessels is a potential explanation for this symptom. Occluded arteries can lead to increased flow through collateral vessels, which function as natural bypasses around the obstruction. This increase in blood flow and resulting shear stress can cause outward remodeling, or arteriogenesis, which improves the efficacy of collaterals. However, following femoral artery ligation in a mouse model of chronic ischemia, vasodilation in the stem region of collateral vessels is impaired at day ...


Vascular Reactivity In Newly-Formed And Mature Arterialized Collateral Capillaries, Sara K. Hellstrom Dec 2014

Vascular Reactivity In Newly-Formed And Mature Arterialized Collateral Capillaries, Sara K. Hellstrom

Master's Theses and Project Reports

Peripheral arterial occlusive disease (PAOD) is a globally-prevalent cardiovascular disease in which atherosclerotic plaques narrow arterial lumen diameters and restrict blood flow to downstream tissues. The impact of these occlusions can be mitigated by collateral vessels that connect parallel arterial branches and act as natural bypasses to maintain perfusion. In animal models that lack collateral arterioles, capillaries that connect terminal arteriolar segments can arterialize and form functional collaterals following an ischemic event; however, in the early stages of development, vasodilation is impaired. We explored the mechanism of impaired vasodilation in arterialized collateral capillaries (ACCs) and pre-existing collaterals (PECs) by evaluating ...


Microvascular Topology And Intravascular Endothelial Cell Labeling In The Gracilis Anterior Muscle Of Balb/C Mice, Paul Heckler Ii Aug 2014

Microvascular Topology And Intravascular Endothelial Cell Labeling In The Gracilis Anterior Muscle Of Balb/C Mice, Paul Heckler Ii

Biomedical Engineering

Peripheral arterial occlusive disease (PAOD) affects approximately 200 million individuals globally. The major underlying cause of PAOD is an inflammatory disease known as atherosclerosis, which results from the build-up of low-density lipoproteins (LDL) in the sub-intimal space. This initiates a complex cascade of events that lead to plaque growth. Plaque growth can then expand into the lumen of the vessel and result in occlusion and/or thrombosis. Symptoms of the disease can include claudication, ulcers, and/or gangrene, although many patients are asymptomatic. Similar to other forms of ischemic disease, risk factors for PAOD include hypertension, diabetes, and smoking. Common ...


Functional Vasodilation Is Impaired In Arterialized Capillaries In The Spinotrapezius, Joshua P. Cutts Jun 2014

Functional Vasodilation Is Impaired In Arterialized Capillaries In The Spinotrapezius, Joshua P. Cutts

Biomedical Engineering

Ischemic diseases are the result of atherosclerotic plaques, which occlude conduit arteries. Ischemic disease in different tissues leads to different conditions, such as coronary artery disease (CHD), cerebrovascular disease (CVD), and peripheral arterial occlusive disease (PAOD). Patient vasculature architecture is variable; some patients having many collateral vessels, which are connect one arterial branch to another, and readily serve as natural bypass routes to atherosclerotic occlusions, to enlarge and provide blood flow to tissue distal to the occlusion. Patients with many natural collateral vessels are ischemia protected. Unfortunately, not all patients have collateral arterioles to remodel into conduit vessels and provide ...