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Biomedical Engineering and Bioengineering Commons™
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California Polytechnic State University, San Luis Obispo
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Full-Text Articles in Biomedical Engineering and Bioengineering
Sex Differences In Collateral Remodeling Following Hindlimb Arterial Occlusion, Laura Burckhardt
Sex Differences In Collateral Remodeling Following Hindlimb Arterial Occlusion, Laura Burckhardt
Master's Theses
Clinical evidence indicates a higher incidence of peripheral arterial occlusive disease and associated likelihood of critical limb ischemia in women, as well as worse prognosis and decreased survival post myocardial infarction. Therefore, understanding the possible differences in underlying vascular compensation mechanisms is crucial. With arterial occlusions, necrosis and tissue injury can be naturally mitigated by the collateral circulation, improving patient prognosis. Previous sex-comparison studies describing differences in vascular remodeling are inconsistent. Therefore, the aim of this study was to describe the effect of arterial occlusion on collateral remodeling in healthy male and healthy reproductive-stage female mice. At 7 days following …
The Impacts Of Arterial Occlusion, Sex, And Exercise On Arteriogenesis And Functional Vasodilation, Megan Tze-Mei Chu
The Impacts Of Arterial Occlusion, Sex, And Exercise On Arteriogenesis And Functional Vasodilation, Megan Tze-Mei Chu
Master's Theses
The most frequent clinical presentation of peripheral arterial occlusive disease (PAOD) is intermittent claudication, which may be caused by impaired vasodilation. Patients demonstrate both local and systemic impairments in vasodilation, but as the collateral circulation is the primary site of resistance to the ischemic zone, impaired collateral vasodilation would have the greatest potential to induce claudication. Collateral function following arterial occlusion is not well defined, but immature collaterals may demonstrate impaired vasodilation in animal models, although this is potentially improved with exercise training. Furthermore, as females exhibit poorer physical function with ischemia and less improvement with therapeutic exercise, there appears …
Measuring Blood Flow In The Skeletal Muscle Microcirculation Using Laser Speckle Flowmetry, Kenneth Howard Gouin Iii
Measuring Blood Flow In The Skeletal Muscle Microcirculation Using Laser Speckle Flowmetry, Kenneth Howard Gouin Iii
Biomedical Engineering
The presence of a native collateral circulation, which serves as a natural bypass for blood flow around an occlusion, improves prognosis for patients with ischemic diseases, such as peripheral arterial occlusive disease (PAOD). However, not all patients have a native collateral circulation, and animal models suggest a genetic basis for this variability. In mice, such as the BALB/c, that lack native arteriolar collaterals, neocollateral formation from capillaries that connect two arterial trees can occur after arterial occlusion, resulting in reperfusion of the ischemic watershed. Immature arterialized collateral capillaries (ACCs) at 7 days post arterial occlusion do not vasodilate in response …