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Full-Text Articles in Biomedical Engineering and Bioengineering
Easy Adjustable Protective Helmet, Ryan Balash
Easy Adjustable Protective Helmet, Ryan Balash
Williams Honors College, Honors Research Projects
Akron Children’s Hospital and The University of Akron’s Biomedical Engineering Design Team Engineering Forward have paired together to improve medical adapted helmets for post-operative and disabled patients. An issue is the helmets are only produced in a couple of sizes. Also, it is a tedious process to constantly adjust the pressure on the patient’s cranium within a trial-and-error process. Engineering Forward plans to improve the effectiveness of this helmet by creating an adjustable helmet that can read the pressure on a patient’s head. The caregiver can then make the necessary adjustments to the helmet to accommodate the patient. Documents of …
Novel Mechanisms Underlying Warm-Up And Percussion Myotonia In Myotonia Congenita, Kevin Richard Nnovak
Novel Mechanisms Underlying Warm-Up And Percussion Myotonia In Myotonia Congenita, Kevin Richard Nnovak
Browse all Theses and Dissertations
Patients with myotonia congenita have muscle hyperexcitability due to loss-of-function mutations in the ClC-1 chloride channel in skeletal muscle, which causes spontaneous firing of muscle action potentials (myotonia), producing muscle stiffness. Triggers for myotonia can occur voluntarily at the neuromuscular junction or involuntarily by striking the muscle with a reflex hammer (percussion myotonia). In patients, muscle stiffness lessens with exercise, a change known as the warm-up phenomenon. Our goal was to identify the mechanism underlying warm-up and percussion myotonia and to use this information to guide development of novel therapies. To determine these underlying mechanisms, we used a drug to …
Nitric Oxide Releasing Polymers For Vascular Graft Applications, Ifeanyi U. Onyejekwe
Nitric Oxide Releasing Polymers For Vascular Graft Applications, Ifeanyi U. Onyejekwe
Biomedical and Chemical Engineering - Dissertations
Nitric oxide [NO] is an endogenous gas involved in a multitude of physiological functions, ranging from vasodilatation, inflammatory response to inhibition of platelet aggregation. Significant interest exists for therapeutic application of exogenous NO, particularly for the improvement of foreign-body responses of biomaterials. One challenge amongst several others that must be taken into consideration is NO's short half-life, ranging from 2-3 s, in physiological systems. Researchers have worked on synthesizing materials, formally referred to as NO donors/NONOates capable of preserving NO and spontaneous gas release upon contact with blood under physiological conditions. Two groups of these commercially available NO donors known …