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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Molecular, Cellular, and Tissue Engineering

Apoptosis

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Full-Text Articles in Biomedical Engineering and Bioengineering

Studying The Role Of Cell Competition In Tumor Progression Via A Two-Dimensional Vertex Model, Bixi Kang Jan 2017

Studying The Role Of Cell Competition In Tumor Progression Via A Two-Dimensional Vertex Model, Bixi Kang

Theses and Dissertations

Tumor progression fate relies on the cell competition between tumorous cells and the surrounding regular cells. Studies on the Drosophila wing imaginal disc illustrate that cell competition can act either as a tumor suppressing or as a tumor promoting mechanism. However, how cell competition alters its role in tumor development via underlying molecular mechanisms as well as the role played by mechanical effects is still poorly understood. Here we study the role of cell competition in the early stage of tumor progression, using a simulation code of epithelial tissue (TiFoSi), which allows to include feedback between tissue growth, mechanics and ...


Regulation Of Tgf-Β1-Induced Apoptosis And Epithelial-Mesenchymal Transition By Matrix Rigidity, Jennifer L. Leight May 2011

Regulation Of Tgf-Β1-Induced Apoptosis And Epithelial-Mesenchymal Transition By Matrix Rigidity, Jennifer L. Leight

Publicly Accessible Penn Dissertations

Transforming growth factor-β (TGF-β) plays an important role in several diseases that characteristically involve changes in tissue rigidity, such as cancer and tissue fibrosis. To determine whether matrix rigidity regulates the effects of TGF-β, we examined NMuMG and MDCK epithelial cells cultured on polyacrylamide gels with varying rigidity and treated with TGF-β1. Decreasing matrix rigidity reduced cell spreading and increased TGF-β1-induced apoptosis, while increasing matrix rigidity resulted in epithelial-mesenchymal transition (EMT). To more carefully control cell spreading, microcontact printing was used to restrict ECM area and revealed that reducing cell spreading also increased apoptosis. Apoptosis on compliant substrates was associated ...