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Full-Text Articles in Biomedical Engineering and Bioengineering

Tissue-Engineered Vascular Grafts: Recellularisation And Surface Functionalisation With Hybrid Magnetic Nanomedicine Developed With Theranostic Potential, Tatiane Eufrásio Da Silva Jul 2018

Tissue-Engineered Vascular Grafts: Recellularisation And Surface Functionalisation With Hybrid Magnetic Nanomedicine Developed With Theranostic Potential, Tatiane Eufrásio Da Silva

PhD theses

Cardiovascular Disease is the number one cause of death in the world, with a mortality rate, globally of 35.1% representing 17.6 million lives lost annually. The majority of these deaths are related to vascular diseases, such as atherosclerotic plaques, which can obstruct blood flow perfusion of organs and tissue causing serious injuries or even death. In the heart, in order to prevent heart failure, blood flow to the tissue must be restored as quickly as possible, ideally via minimally invasive interventions such as stenting or other types of angioplasty as the gold standard. However, this is not always ...


Collagen And Elastin Based Tissue Engineered Vascular Grafts, Alan J. Ryan Feb 2016

Collagen And Elastin Based Tissue Engineered Vascular Grafts, Alan J. Ryan

PhD theses

Cardiovascular disease is the leading cause of death worldwide, accounting for 29% of all global deaths and is set to rise to 23 million deaths a year by 2030 (World Health Organisation, 2012). Arterial bypassing, both peripheral and coronary, is usually performed with autologously harvested vessels. However, the quantity available is often very limited as well as the vessels of elderly patients often suffering from thrombus, aneurysm formation or arthrosclerosis in high pressure arterial sites. The shortcomings of autografts has led to a substantial amount of research being directed towards tissue engineered vascular grafts (TEVGs) (Kakisis et al., 2005). Currently ...


Development Of A Microrna Delivery Scaffold System For Bone Tissue Engineering, Irene Mencía Castaño Oct 2015

Development Of A Microrna Delivery Scaffold System For Bone Tissue Engineering, Irene Mencía Castaño

PhD theses

Although bone has an intrinsic capacity for self repair, the healing of large bone defects that typically present in humans often involves complications which result in failure to heal, leading to delayed or non-union of the defect. Due to limitations of current therapeutic approaches of autografting and allografting, the use of tissue engineered scaffolds has emerged. Despite some success with this approach, these scaffolds often require a further stimulus to promote complete healing of large bone defects. microRNAs (miRNAs) have recently emerged as promising therapeutics to stimulate bone repair, owing to their ability to intercept entire gene cohorts. However, the ...