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Full-Text Articles in Biomedical Engineering and Bioengineering
Elucidating The Mechanical, Structural, Functional, And Molecular Mechanisms Involved In Irreversible Vascular Changes In Aortic Coarctation, Brandon Wegter
Elucidating The Mechanical, Structural, Functional, And Molecular Mechanisms Involved In Irreversible Vascular Changes In Aortic Coarctation, Brandon Wegter
Master's Theses (2009 -)
Coarctation of the aorta (CoA) is a constriction of the thoracic aorta and is one of the most common congenital cardiovascular defects. Treatment by surgical correction has saved the lives of thousands of children, but many still have a reduced lifespan due to hypertension. Previous results using our novel rabbit model showed that the current treatment guideline of a 20 mmHg blood pressure gradient (BPG) induces irreversible vascular changes, which persisted despite correction. Preliminary data of the downregulation of natriuretic peptide receptor C (NPR-C) in proximal aortic tissue of human patients with CoA serves as the possible underlying mechanism for …
Characterization Of Histological Changes In The Microvasculature Of Rat Skeletal Muscle After Spinal Cord Injury, Sally Lin
Master's Theses (2009 -)
The purpose of this study was to determine whether there are histological changes in the microvasculature of rat skeletal muscle following chronic spinal cord injury both above and below the level of injury. This study is important because microvascular structure likely impacts muscle performance and cardiovascular health. To the best of our knowledge, this is the only study to investigate microvascular structure within rat skeletal muscle after spinal cord injury. We hypothesized structural remodeling would occur in both the myofibers and microvasculature, which would then manifest in differences in myofiber cross sectional area and microvascular diameter, wall thickness, wall to …