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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Life Sciences

Retrospective Theses and Dissertations

2007

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Full-Text Articles in Biomedical Engineering and Bioengineering

Osteoarthritis: Clinical Evaluation And Cartilage Tissue Engineering, Wanda June Gordon-Evans Jan 2007

Osteoarthritis: Clinical Evaluation And Cartilage Tissue Engineering, Wanda June Gordon-Evans

Retrospective Theses and Dissertations

Osteoarthritis (OA) is the 2nd leading cause of long term disability in North America affecting 40 million Americans. The work presented in this manuscript addresses clinical outcome measures used to determine treatment effect and 2 in vitro studies using tissue engineering techniques to grow cartilage suitable for in vivo use. In the first study, radiographs of the stifle joint in dogs were scored for the severity of OA, and limb function was measured by force platform gait analysis. The 2 outcome measures were analyzed using regression methods. There was no correlation of the severity of radiographic OA and limb function ...