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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Life Sciences

Retrospective Theses and Dissertations

1992

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Full-Text Articles in Biomedical Engineering and Bioengineering

Transcranial Doppler Sonography: A New Noninvasive Method For Measuring Toxicant-Induced Alterations In Cerebral Blood Flow , Michael Edward Drues Jan 1992

Transcranial Doppler Sonography: A New Noninvasive Method For Measuring Toxicant-Induced Alterations In Cerebral Blood Flow , Michael Edward Drues

Retrospective Theses and Dissertations

The purpose of this experiment was to use transcranial Doppler sonography (TCD) in the dog to noninvasively measure changes in cerebral blood flow (CBF) resulting from a low-level exposure to the commonly used pyrethroid insecticide deltamethrin. Deltamethrin has previously been shown to increase CBF in rats as determined by other techniques. In this experiment, deltamethrin was dissolved in glycerol-formal solvent and administered intravenously at dosage levels of 5% and 10% of the LD[subscript]50 value to 12 adult dogs 48 hours apart. It was expected that vascular changes resulting from these low-level deltamethrin exposures would be subtle and occur ...