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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Life Sciences

University of Colorado, Boulder

Computational model

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The Coordination Of Movement From Motor Units To Muscle Synergies, Daniel Francis Feeney Jan 2018

The Coordination Of Movement From Motor Units To Muscle Synergies, Daniel Francis Feeney

Integrative Physiology Graduate Theses & Dissertations

This dissertation comprises computational and experimental studies that examined the neuromuscular factors underlying differences in manual dexterity and mobility in health and disease.

The first two studies developed models of motor unit force production. The first model used a Proportional-Integral-Derivative (PID) control algorithm to activate a pool of motor units to simulate the force trajectory during force-matching tasks. The second model comprised a probabilistic state-space model to estimate the common synaptic input to motor neurons based on the discharge times of action potentials by activated motor units. The state-space model demonstrated superior sensitivity compared with previous models.

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