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Full-Text Articles in Biomedical Engineering and Bioengineering
Epithelial-Mesenchymal Crosstalk Influences Cancer-Related Cell Behavior: A 3d Lung Alveolus-Fibroblast Co-Culture System, Jessica Kole Hall
Undergraduate Honors Theses
Lung cancer is a devastating disease that kills more individuals in the United States than any other cancer. The tumor microenvironment is increasingly recognized as playing a major role in the progression of cancer. Thus, studying the interactions among lung cancer cells, non-malignant cells and the surrounding matrix is critical for understanding and treating lung cancer. Three-dimensional in vitro co-culture systems allow for tissue-relevant platforms that better recapitulate the native cell environment. In this work, we employed a cyst templating technique to culture alveolar epithelial cells on photodegradable microspheres and subsequently encapsulated the cell-covered spheres within poly(ethylene glycol) (PEG ...