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Biomedical Engineering and Bioengineering Commons

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Theses/Dissertations

Life Sciences

University of Colorado, Boulder

Civil Engineering Graduate Theses & Dissertations

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Understanding The Mechanics Of Tissue Growth In Engineered Scaffolds: Case Of Cartilage Tissue, Umut Akalp Jan 2017

Understanding The Mechanics Of Tissue Growth In Engineered Scaffolds: Case Of Cartilage Tissue, Umut Akalp

Civil Engineering Graduate Theses & Dissertations

Tissue failure due to aging or diseases reduces the quality of life for individuals. In the case of cartilage tissue, the current solution is to use implants to fulfill the functional duties of native tissue. However, this approach has limitations, such as periodic replacement and number of the required operations. Tissue engineering provides an alternative approach in which the aim is to regenerate the native tissue by a population of cells encapsulated in a scaffold (i.e. hydrogels). Although this approach is promising, there are several limitations regarding the design of these scaffolds which can be overcome only by the ...