Open Access. Powered by Scholars. Published by Universities.®
Biomedical Engineering and Bioengineering Commons™
Open Access. Powered by Scholars. Published by Universities.®
Articles 1 - 3 of 3
Full-Text Articles in Biomedical Engineering and Bioengineering
Myocardial Perfusion Pressure: A Predictor Of 24hour Survival During Prolonged Cardiac Arrest In Dogs, Karl B. Kern, Gordon A. Ewy, William D. Voorhees, Charles F. Babbs, Willis A. Tacker
Myocardial Perfusion Pressure: A Predictor Of 24hour Survival During Prolonged Cardiac Arrest In Dogs, Karl B. Kern, Gordon A. Ewy, William D. Voorhees, Charles F. Babbs, Willis A. Tacker
Weldon School of Biomedical Engineering Faculty Publications
Myocardial perfusion pressure, defined as the aortic diastolic pressure minus the right atria1 diastolic pressure, correlates with coronary blood flow during cardiopulmonary resuscitation (CPR) and predicts initial resuscitation success. Whether this hemodynamic parameter can predict 24-h survival is not known. We examined the relationship between myocardial perfusion pressure and 24-h survival in 60 dogs that underwent prolonged (20 min) ventricular fibrillation and CPR. Forty-two (70%) animals were initially resuscitated and 20 (33%) survived for 24 h. Myocardial perfusion pressure was significantly greater when measured at 5, 10, 15 and 20 min of ventricular fibrillation in the resuscitated animals than in …
A Rapid, Widely Applicable Screen For Drugs That Suppress Free Radical Formation In Ischemia/Reperfusion, Steven C. Salaris, Charles F. Babbs
A Rapid, Widely Applicable Screen For Drugs That Suppress Free Radical Formation In Ischemia/Reperfusion, Steven C. Salaris, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Substantial injury can occur during reoxygenation of previously ischemic tissue in many experimental models, as the result of the generation of oxygen-derived free radicals. To test the antiradical activity of potentially protective compounds in this setting, we developed a simple screening system, applicable to fresh biopsy specimens, in which warm ischemia and reoxygenation of excised tissue are performed in vitro. Tissue production of malondialdehyde (MDA) equivalents is used as a nonspecific-but-sensitive marker of oxygen radical damage. Test compounds with putative antiradical activity are added prior to the reoxygenation phase, and their ability to suppress MDA production is an index of …
A Rapid, Widely Applicable Screen For Drugs That Suppress Free Radical Formation In Ischemia/Reperfusion, Steven C. Salaris, Charles F. Babbs
A Rapid, Widely Applicable Screen For Drugs That Suppress Free Radical Formation In Ischemia/Reperfusion, Steven C. Salaris, Charles F. Babbs
Weldon School of Biomedical Engineering Faculty Publications
Substantial injury can occur during reoxygenation of previously ischemic tissue in many experimental models, as the result of the generation of oxygen-derived free radicals. To test the antiradical activity of potentially protective compounds in this setting, we developed a simple screening system, applicable to fresh biopsy specimens, in which warm ischemia and reoxygenation of excised tissue are performed in vitro. Tissue production of malondialdehyde (MDA) equivalents is used as a nonspecific-but-sensitive marker of oxygen radical damage. Test compounds with putative antiradical activity are added prior to the reoxygenation phase, and their ability to suppress MDA production is an index of …