Biomedical Engineering and Bioengineering Commons^™

Quantitative Assessment Of Reflex Blood Pressure Regulation Using A Dynamic Model Of The Cardiovascular System, Tanha Patel

Theses

A quantitative understanding of the changes in coronary, pulmonary and systemic hemodynamic variables and their effects on the regulation mechanism is important to the better postoperative management of patients with impaired cardiac function. The arterial baroreflex plays a key role in blood pressure homeostasis, and its impairment may result in exaggerated blood pressure fluctuations and an increased risk of cardiovascular morbid events.

The objective of this work was to construct a mathematical model of the cardiovascular system, which will allow us to simulate the effects of the baroreceptor reflex regulation on sudden changes in blood pressure, caused by sudden changes …

A Mathematical Model Of Cardiovascular System With Feedback Control, Jiayu Gu

Theses

A mathematical model of human cardiovascular system is presented in this study. The closed-loop model is composed of twenty compartments which includes the left and right ventricles, and the systemic and pulmonary circulations. Two physiologic feedback control mechanisms, autoregulation of blood flow and baroreceptor reflex regulation of arterial pressure, are incorporated in the model. Autoregulation acts by changing local resistance to blood flow through metabolic and myogenic mechanisms, thereby insuring a match between oxygen supply and demand for any tissue or organ. Baroreceptors act through neural pathways to alter heart rate, contractility and peripheral resistance in order to return sudden …