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Biomedical Engineering and Bioengineering Commons™
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Articles 121 - 127 of 127
Full-Text Articles in Biomedical Engineering and Bioengineering
Inkjet Printing Of Polarized Yeast Cells, Xiuyuan Yang, Kari Clase
Inkjet Printing Of Polarized Yeast Cells, Xiuyuan Yang, Kari Clase
The Summer Undergraduate Research Fellowship (SURF) Symposium
The motivation is to applying engineering knowledge to develop 3D bio-printing in inkjet printer (first stage--monolayer). To achieve the goal, there are three problems to solve. First, we have to figure out regulation of growth of target cells; inability to regulate the location and pattern of growing cells make us even unable to build 3D printer in the direct way. Second problem is how to protect of yeast cells from high temperature and viscous force when printing. The third issue is how to modify the inkjet printer especially the feeding system in order to implement printing on other materials rather …
Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu
Adhesive Elastomeric Proteins, Haefa Mansour, Julie Liu
The Summer Undergraduate Research Fellowship (SURF) Symposium
Sutures and staples commonly used to close surgical wounds tend to be much stiffer than the surrounding tissue, often resulting in external tissue damage. Surgical adhesives provide a promising alternative to these sutures and staples. Ideal surgical adhesives are biocompatible, able to set well and remain sticky in moist conditions, possess strong adhesive and cohesive properties, and exhibit mechanical properties that mimic those of the surrounding tissue. Unfortunately, the adhesives available today are unable to satisfactorily meet all of these criteria. We are utilizing protein engineering techniques to design, create, and test a new surgical adhesive that combines the adhesive …
A Quantitative Analysis Of A Paper-Based, Laser-Defined, Oxygen-Generating Platform For Chronic Wounds, Tiffany L. Huang, Babak Ziaie
A Quantitative Analysis Of A Paper-Based, Laser-Defined, Oxygen-Generating Platform For Chronic Wounds, Tiffany L. Huang, Babak Ziaie
The Summer Undergraduate Research Fellowship (SURF) Symposium
Chronic wounds affect 6.5 million patients a year while consuming US$25 billion in health care costs (Sen 2009 Wound Repair Regen.). Despite advances in wound management therapies, modern treatment for chronic wounds still requires continual professional attention and expensive equipment, posing serious practical and financial burdens for the regular patient. To provide an alternative solution, we are developing a low-cost smart bandage platform that integrates actuators and sensors to monitor and treat chronic wounds. One component of the integrated platform is an oxygen-generating module. It is a polydimethylsiloxane (PDMS) based microfluidic device fabricated on a parchment paper substrate that …
Development Of Non-Invasive In Vivo Ultrasound Imaging Techniques For Elastase-Induced Experimental Abdominal Aortic Aneurysms, Alexa A. Yrineo, Elizabeth A. Nunamaker, Hilary D. Schroeder, Amy E. Bogucki, Craig J. Goergen
Development Of Non-Invasive In Vivo Ultrasound Imaging Techniques For Elastase-Induced Experimental Abdominal Aortic Aneurysms, Alexa A. Yrineo, Elizabeth A. Nunamaker, Hilary D. Schroeder, Amy E. Bogucki, Craig J. Goergen
The Summer Undergraduate Research Fellowship (SURF) Symposium
Abdominal aortic aneurysms (AAAs) are pathological dilations of the aorta which are associated with significant morbidity and mortality. The underlying mechanisms that cause this inflammatory disease are not fully understood and thus, are currently under investigation. In the hopes of preventing disease progression, rodent models that mimic the human condition have been developed to provide insight into the pathogenesis of AAAs. In this study, porcine pancreatic elastase (0.44 U; Sigma-Aldrich) was infused into the infrarenal aortas of male, Sprague Dawley rats to induce aneurysms. To perform the surgery, temporary ligatures were placed around proximal and distal sections of the abdominal …
Direct Quantitative Analysis Of Biomarkers Using Mass Spectrometry, Morgan N. Mcluckey, Zheng Ouyang
Direct Quantitative Analysis Of Biomarkers Using Mass Spectrometry, Morgan N. Mcluckey, Zheng Ouyang
The Summer Undergraduate Research Fellowship (SURF) Symposium
Point-of-care (POC) diagnostics describes a step in the medical treatment process where drugs can be monitored in a patient’s body on-site and in a timely fashion. Mass spectrometry (MS) can provide a quick, efficient, and highly accurate method of analysis of patient biofluids and tissues. Developing methods to bring this diagnostic mechanism to hospitals and clinics has the potential to improve patient care through, for example, personalized medicine. Our goal was to develop a way to effectively introduce internal standard (IS), a necessary chemical for the analytical process, to low-volume biofluid samples. Additionally, the effective direct quantitation of biomarkers with …
Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu
Iron-Magnesium Alloy Bioabsorbable Blood Stent, Kaitlyn Jarry, L Stanciu
The Summer Undergraduate Research Fellowship (SURF) Symposium
Bioabsorbable materials are fairly new and proper alloys for implantation in the body have not yet been established. There are a few polymers that have showed promise, but they do not provide the proper mechanical support that metal does. These materials would be used to create devices such as blood stents and orthopedic screws. Investigation into the properties of different alloys can help to establish a material that can be used for implanted devices that are only needed for a limited amount of time. In order to investigate these alloys many different experiments will to be run to test the …
Characterization Of The Saturation Level Of Nucleosome Arrays And Plasmids By Mnase Digestion, Wenjie Liu, Nathan Nurse, Chongli Yuan
Characterization Of The Saturation Level Of Nucleosome Arrays And Plasmids By Mnase Digestion, Wenjie Liu, Nathan Nurse, Chongli Yuan
The Summer Undergraduate Research Fellowship (SURF) Symposium
Studying processes involving DNA such as DNA replication and transcription is best done in the context of chromatin because the structure of DNA influences the efficiency of such processes. Chromatin structure is derived from DNA wrapping around histone octamers with the histone octamer density termed saturation level. For in vitro studies on DNA replication and transcription, it is important to maintain a constant saturation level so that saturation level can be removed as a variable. Our goal is to characterize the saturation level of plasmids using the rate of MNase digestion. MNase digestions were first performed on reconstituted nucleosome arrays …