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Full-Text Articles in Biomedical Engineering and Bioengineering
Collapsible Silicone Tubes: An In Vitro Model For Tracheal Traction, Kevin D. Garman
Collapsible Silicone Tubes: An In Vitro Model For Tracheal Traction, Kevin D. Garman
Master's Theses (2009 -)
Obstructive sleep apnea (OSA) is characterized by recurrent episodes of airway collapse and airflow limitation during sleep. Fragmented sleep and reductions in blood oxygen saturation lead to several comorbidities, including hypertension, cardiovascular disease, and cerebrovascular disease. Longitudinal forces (tracheal traction) acting on the soft tissues surrounding the upper airway have been proposed to play a significant role in stabilizing the airway and preventing collapse. However, the relative contribution of longitudinal forces as compared to other factors that affect airway stability (airway geometry, tissue properties, muscle activity) remains unclear. This in-vitro study aimed to investigate to what extent longitudinal forces can …
Effects Of Random Oscillations On Balance Control In Healthy Young Adults, Jacob Van Dehy
Effects Of Random Oscillations On Balance Control In Healthy Young Adults, Jacob Van Dehy
Master's Theses (2009 -)
In human walking, balance control is managed through proactive changes in spatio-temporal parameters of stepping [1]. It has been suggested that continuous disruptions to healthy young adult balance cause greater changes to overall variability of these parameters than a shift in the mean stepping parameters [2]. This suggests that walking may be occurring in a more reactive manner, modulating to maintain balance without increasing the mean significantly. Work using continuous oscillations to treadmill walking suggest there is an interplay between the predictability of a signal used to disrupt subject balance and the degree to which compensation occurs [3]. To determine …
Elucidating The Mechanical, Structural, Functional, And Molecular Mechanisms Involved In Irreversible Vascular Changes In Aortic Coarctation, Brandon Wegter
Elucidating The Mechanical, Structural, Functional, And Molecular Mechanisms Involved In Irreversible Vascular Changes In Aortic Coarctation, Brandon Wegter
Master's Theses (2009 -)
Coarctation of the aorta (CoA) is a constriction of the thoracic aorta and is one of the most common congenital cardiovascular defects. Treatment by surgical correction has saved the lives of thousands of children, but many still have a reduced lifespan due to hypertension. Previous results using our novel rabbit model showed that the current treatment guideline of a 20 mmHg blood pressure gradient (BPG) induces irreversible vascular changes, which persisted despite correction. Preliminary data of the downregulation of natriuretic peptide receptor C (NPR-C) in proximal aortic tissue of human patients with CoA serves as the possible underlying mechanism for …
Evaluating Wall Shear Stress Indices To Uncover Stimuli For Restenosis And Malapposition In Stented Coronary Arteries, Ali A. Aleiou
Evaluating Wall Shear Stress Indices To Uncover Stimuli For Restenosis And Malapposition In Stented Coronary Arteries, Ali A. Aleiou
Master's Theses (2009 -)
The cause of coronary artery neointimal thickening leading to restenosis in ~10% of drug-eluting stents is unknown. Although research suggests adverse values of traditional wall shear stress (WSS) indices may contribute, studies to date have not accounted for stent geometry, which dictates local WSS patterns influencing drug concentration. Recently proposed WSS indices such as WSS variability and WSS exposure time (WSSET) may shed further light on restenosis or, the opposite effect, resorption. The objective of this investigation was to locally evaluate traditional and recently proposed post-stenting metrics and their respective impact on restenosis or resorption. This study used de-identified data …
Developing An Imaging Biomarker To Detect Aberrant Brain Connectivity In Individual Patients, Esther Cox
Developing An Imaging Biomarker To Detect Aberrant Brain Connectivity In Individual Patients, Esther Cox
Master's Theses (2009 -)
Resting state functional MRI (rsfMRI) has been proven to be a valuable tool in clinical applications such as pre-surgical mapping, but there is not yet a functional and usable algorithm that can be used by physicians in a clinical setting to evaluate an individual patient for diseases and aberrant brain connectivity. If a physician wants to evaluate a patient in this way, the rsfMRI data must be looked at “by hand,” i.e. the physician must manually evaluate the data and identify the functional ICN’s and whether they are normal or aberrant. An algorithm that would automate this process and supplement …