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Graduate Theses and Dissertations

Microfiltration

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Full-Text Articles in Biomedical Engineering and Bioengineering

Optofluidic Spectroscopy Platform For Detection Of Hemolysis, Edikan Archibong Nov 2015

Optofluidic Spectroscopy Platform For Detection Of Hemolysis, Edikan Archibong

Graduate Theses and Dissertations

In the United States alone, hundreds of millions of blood tests are performed annually, and a significant number of those tests are compromised due to hemolysis: e.g., 31% compromised in emergency rooms (inpatient) and 10% at blood banks, clinics, and other outpatient venues. Currently there is no way to reliably detect hemolysis without plasma separation. As a result, significant delays ensue, potentially negatively affecting patient diagnosis and treatment. In addition to in vitro hemolysis, which compromises the quality of blood tests, hemolysis can also occur in vivo. The in vivo occurrence of hemolysis is an indication of life-threatening complications ...


Membrane-Based Separations For Solid/Liquid Clarification And Protein Purification, Matthew Thomas Aspelund Jan 2010

Membrane-Based Separations For Solid/Liquid Clarification And Protein Purification, Matthew Thomas Aspelund

Graduate Theses and Dissertations

Recombinant protein technology has become increasingly important in recent years. Recombinant proteins can be found in everything from pharmaceuticals to detergents. The increasing demand and the high cost associated with the production and purification of recombinant proteins highlights the need to develop efficient and inexpensive methods for the solid/liquid clarification and purification of these proteins. Membrane technologies, which offer the advantage of high throughput and ever-improving selectivity, have the potential to meet the increased demands placed on the downstream processing of recombinant proteins. The overall objective of this work was to develop methods for the solid/liquid clarification and ...